THE EFFECT OF GENISTEIN AND ISOFLAVONE METABOLITES ON CALCIUM ABSORPTION AND

染料木黄酮和异黄酮代谢物对钙吸收和吸收的影响

• 批准号: 7717567
• 负责人: MUNRO PEACOCK
• 金额: $ 0.01万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717567
• 关键词: Biochemical Markers; Bone Density; Bone Resorption; Botanicals; Calcium; Computer Retrieval of Information on Scientific Projects Database; Diet; Dose; Effectiveness; Estrogen Replacement Therapy; Estrogens; Excretory function; Funding; Genistein; Grant; Individual; Institution; Invasive; Isoflavones; Isotopes; Kinetics; Label; Life; Marketing; Measures; Monitor; Osteoporosis; Postmenopause; Research; Research Personnel; Resources; Skeleton; Source; United States National Institutes of Health; Urine; Woman; absorption; accelerator mass spectrometry; bone; bone health; bone turnover; dosage; equol; innovation; prevent; response; risedronate sodium; soy protein isolate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Several types of botanical products containing isoflavones are being marketed as an alternative to estrogen replacement therapy to prevent osteoporosis in postmenopausal women. Estrogen suppresses bone resorption and may increase calcium absorption. Efficacy of isoflavones on bone health has mixed results which may depend on the dose and interaction of isoflavones and the ability of individuals to produce equal. This project will determine the dose response of effect of genistein and the interaction with other soy isoflavones on calcium absorption and bone resorption in postmenopausal women who are equol vs. nonequol producers. We will use 41Ca, a long-lived isotope, to label the skeleton and an Accelerator Mass Spectrometry (AMS) to monitor perturbations by diet. This innovative approach to study bone resorption is a direct measure of bone resorption in contrast to biochemical markers of bone turnover and traditional calcium kinetics, rapid compared to studying changes in bone density, and not as invasive as bone histomorphometry. We are able to systematically determine the effect of various types and dosages of isoflavone-containing botanical products sequentially in the same postmenopausal women for their effectiveness in suppressing bone resorption by measuring changes in 41Ca excretion in the urine. As a positive control the effect of isoflavones will be compared to Actonel , a common osteoporosis treatment therapy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 几种含有异黄酮的植物产品正在上市，作为雌激素替代疗法的替代品，以预防绝经后妇女骨质疏松症。 雌激素抑制骨吸收并可能增加钙吸收。 异黄酮对骨骼健康的功效有好坏参半的结果，这可能取决于异黄酮的剂量和相互作用以及个体产生等黄酮的能力。 该项目将确定金雀异黄酮作用的剂量反应以及与其他大豆异黄酮的相互作用对雌马酚和苯马酚生产者的绝经后妇女的钙吸收和骨吸收的影响。 我们将使用 41Ca（一种长寿命同位素）来标记骨骼，并使用加速器质谱 (AMS) 来监测饮食的干扰。 与骨转换的生化标记物和传统的钙动力学相比，这种研究骨吸收的创新方法是骨吸收的直接测量，与研究骨密度的变化相比，速度更快，并且不像骨组织形态测量那样具有侵入性。 我们能够通过测量尿液中 41Ca 排泄的变化，系统地确定不同类型和剂量的含异黄酮植物产品对同一绝经后女性的抑制骨吸收的效果。 作为阳性对照，异黄酮的效果将与常见的骨质疏松症治疗药物 Actonel 进行比较。