SKIN SURFACE COOLING TO IMPROVE ORTHOSTATIC TOLERANCE AFTER PROLONGED BED REST

皮肤表面冷却可提高长时间卧床休息后的体位耐受力

• 批准号: 7377651
• 负责人: CRAIG G CRANDALL
• 金额: $ 9.12万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377651
• 关键词: SKIN; SURFACE; COOLING; IMPROVE; ORTHOSTATIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Orthostatic intolerance is a common occurence following space flight, following prolonged bed rest, and in over 500,000 Americans who suffer from idiopathic orthostatic intolerance. With respect to space flight, 25-66% of all astronauts experience syncope or syncopal symptoms during a stand test 2-3 hours after landing. In addition, many astronauts experience orthostatic hypotension/intolerance during reentry of the space shuttle when gravitational forces are greater than 1.0 Gz (i.e. head to foot vector) for 10-15 min, and peak as high as 1.8 Gz. This high incidence of orthostatic intolerance is of substantial concern to NASA due to obvious operational and safety issues for the astronauts. Thus, NASA has placed a high priority on identifying an effective countermeasure to reduce the incidence of orthostatic intolerance associated with prolonged microgravity exposure. Identification of such a countermeasure may also benefit individuals with idiopathic orthostatic intolerance.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。直立不耐受是太空飞行后、长时间卧床休息后常见的现象，超过 500,000 名美国人患有特发性直立不耐受。在太空飞行方面，25-66%的宇航员在着陆后2-3小时的站立测试中出现晕厥或晕厥症状。此外，许多宇航员在航天飞机重返大气层期间，当重力大于 1.0 Gz（即头到脚矢量）持续 10-15 分钟，并且峰值高达 1.8 Gz 时，会出现直立性低血压/不耐受。由于宇航员明显的操作和安全问题，这种直立不耐受的高发生率引起了 NASA 的极大关注。因此，美国宇航局高度重视确定有效的对策，以减少与长期微重力暴露相关的直立不耐受的发生率。确定这种对策也可能使患有特发性直立不耐受的个体受益。