SKIN SURFACE COOLING TO IMPROVE ORTHOSTATIC TOLERANCE AFTER PROLONGED BED REST

皮肤表面冷却可提高长时间卧床休息后的体位耐受力

• 批准号: 7377651
• 负责人: CRAIG G CRANDALL
• 金额: $ 9.12万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377651
• 关键词: SKIN; SURFACE; COOLING; IMPROVE; ORTHOSTATIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Orthostatic intolerance is a common occurence following space flight, following prolonged bed rest, and in over 500,000 Americans who suffer from idiopathic orthostatic intolerance. With respect to space flight, 25-66% of all astronauts experience syncope or syncopal symptoms during a stand test 2-3 hours after landing. In addition, many astronauts experience orthostatic hypotension/intolerance during reentry of the space shuttle when gravitational forces are greater than 1.0 Gz (i.e. head to foot vector) for 10-15 min, and peak as high as 1.8 Gz. This high incidence of orthostatic intolerance is of substantial concern to NASA due to obvious operational and safety issues for the astronauts. Thus, NASA has placed a high priority on identifying an effective countermeasure to reduce the incidence of orthostatic intolerance associated with prolonged microgravity exposure. Identification of such a countermeasure may also benefit individuals with idiopathic orthostatic intolerance.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。长时间的床休息后，在太空飞行后，以及有50万以上患有特发性正常不稳定的美国人，体位不耐受是一个普遍的情况。关于太空飞行，所有宇航员中有25-66％在降落后2-3小时内经历了晕厥或晕厥症状。此外，当引力大于1.0 Gz（即前往步载体）10-15分钟，高达1.8 gz时，许多宇航员在航天飞机重新进入时会经历正常的低血压/不耐受。由于宇航员明显的操作和安全问题，直达不稳定不耐受的高发病率令人担忧。因此，NASA在确定有效的对策方面将高度优先考虑与长时间的微重力暴露相关的对抗率。对这种对策的识别也可能使特发性正常不宽容的人受益。