Optical Imaging of Tactile Information in S1 Cortex

S1 皮层触觉信息的光学成像

• 批准号: 7688219
• 负责人: RICHARD A FRIEDMAN
• 金额: $ 49.09万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688219
• 关键词: Address; Area; Attention; Behavior; Brain; Code; Complement; Complex; Cues; Data; Depth; Development; Digit structure; Discrimination; Dyes; Exhibits; Functional Magnetic Resonance Imaging; Goals; Hand; Image; Location; Maps; Mechanoreceptors; Methods; Monkeys; Motion; Motion Perception; Movement; Nature; Neurons; Parietal; Perception; Process; Prosthesis; Psychophysiology; Recovery of Function; Resolution; Role; Signal Transduction; Skin; Somatosensory Cortex; Speed; Staging; Stimulus; Stroke; Structure; Surface; Tactile; Texture; Visual system structure; abstracting; clinically relevant; neural circuit; object motion; object shape; optical imaging; receptor; research study; response; somatosensory; spatiotemporal; ventral intraparietal area; voltage

PROJECT SUMMARY/ABSTRACT The goal of this proposal is to investigate how the brain encodes tactile motion processing in the brain. Responses within two different stages of somatosensory cortical processing, primary (SI) and second (SII) somatosensory cortex, will be examined. Central to understanding their functional roles is finding out what distinguishes one area from another. By using simple versus complex stimuli, we aim to distinguish between areas whose responses are closely associated with the physical nature of the stimulus and areas whose responses are invariant and more closely reflect the motion percept. We will employ optical imaging, voltage sensitive dye imaging, BOLD fMRI, single unit recording, and anatomical tracing methods to address these questions. These experiments will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for, for example, recovery of function from stroke and development of tactile prosthetics.

项目摘要/摘要 该建议的目的是研究大脑如何编码大脑中的触觉运动处理。 在体感皮质加工，主要（SI）和第二（SII）的两个不同阶段的响应 体验皮层将进行检查。了解其功能角色的核心是找出什么 将一个区域与另一个区域区分开。通过使用简单与复杂刺激，我们旨在区分 响应与刺激和区域的物理性质紧密相关的区域 响应是不变的，更紧密地反映了运动感知。我们将采用光学成像，电压 敏感的染料成像，大胆的fMRI，单个单元记录和解剖方法来解决这些方法 问题。这些实验将阐明触觉行为和注意力的神经电路， 了解这将具有临床相关性，例如从中风恢复和 触觉假肢的发展。