A Course in Computational Genomics for Experimentalists

实验者计算基因组学课程

• 批准号: 6773276
• 负责人: RICHARD A FRIEDMAN
• 金额: $ 4.82万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-11 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6773276
• 关键词: bioinformatics; computer data analysis; curriculum; education evaluation /planning; educational resource design /development; experimental designs; functional /structural genomics; molecular biology information system; science education

DESCRIPTION (provided by applicant): The aim of this project is to develop a lecture/laboratory course in bioinformatics that teaches graduate students in the various experimental biomedical disciplines how to analyze and integrate genomic data in their research. Rather than simply offering a course in bioinformatic methods, it is proposed to develop a set of several illustrative biological problems that require genomic analysis for their solution, A series of lessons will be developed that cover the methods for relating the sequences of proteins and nucleic acids to their structure, function, evolution, expression, and role in human health and disease, The theoretical basis of all methods studied will be taught. The operation of all programs used will be demonstrated live, with the aid of an LCD projector. The students will gain experience in using all the methods themselves by applying them to real biological problems in a supervised computer laboratory. Most of the lab exercises will involve a term project in which the students explore the structure and function of a protein/gene family involved in cellular signaling. Other exercises will include finding a human disease gene by a combination of linkage and sequence analysis, and analyzing microarray expression data. Emphasis will be placed on the use of web-accessible databases.

描述（由申请人提供）：该项目的目的是开发生物信息学的讲座/实验室课程，该课程在各种实验生物医学学科中教授研究生如何分析和整合其研究中的基因组数据。建议开发一系列的经验教训，涵盖将蛋白质和核酸序列与其结构，功能，功能，进化，进化，以及在人类健康和疾病中的作用，将在人类健康和疾病中的作用，将在所有方法中都在所有方法中。在LCD投影仪的帮助下，所有使用的程序的操作将现场演示。学生将通过将其应用于监督的计算机实验室中的实际生物学问题来获得使用所有方法的经验。大多数实验室练习都将涉及一个术语项目，在该项目中，学生探索涉及细胞信号传导的蛋白质/基因家族的结构和功能。其他练习将包括通过连锁和序列分析的组合找到人类疾病基因，并分析微阵列表达数据。将重点放在使用Web可访问数据库上。