Fresno Asthmatic Children's Environment Study (FACES)

弗雷斯诺哮喘儿童环境研究 (FACES)

• 批准号: 7392714
• 负责人: Ira B Tager
• 金额: $ 97.42万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-15 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392714
• 关键词: Accounting; Acute; Address; Adverse effects; Air; Air Pollutants; Air Pollution; Antioxidants; Asthma; Birth; Bronchodilator Agents; CD14 gene; California; Carbon; Characteristics; Child; Childhood Asthma; Classification; Cohort Studies; DNA; Daily; Data; Endotoxins; Environment; Enzymes; Etiology; Evaluation; Exposure to; Funding; Fungal Spores; Future; Genes; Genetic Polymorphism; Goals; Growth; Health; Individual; Long-Term Effects; Longitudinal Studies; Medical Care Costs; Methods; Morbidity - disease rate; Office Visits; Outcome; Oxidants; Ozone; Pollen; Predisposition; Questionnaires; Recording of previous events; Research; Resources; Respiratory physiology; Role; Series; Severities; Specimen; Spirometry; Statistical Methods; Structural Models; Symptoms; atopy; cohort; day; design; follow-up; pollutant; response; sex; trafficking

DESCRIPTION (provided by applicant): To address an important data gap, we propose to continue a longitudinal cohort study, the Fresno Asthmatic Children's Environment Study (FACES), funded by the California Air Resources Board for the last 5 years. The overall goal of the study is to determine if children with asthma who have adverse responses to short- term, daily increases in concentrations of ambient air pollutants and bioaerosols are more likely to have increased long-term asthma morbidity and decreased lung function growth. The specific aims of the study are the following: 1) to evaluate the long-term health effects of exposure to air pollutants/bioaerosols on symptoms, asthma severity, and growth of lung function; 2) to evaluate the effect of interactions between exposures to traffic-related pollutants and bioaerosols on both short-term and long-term effects; 3) to use new methods of causal analysis (marginal structural models) to address Alms 1 and 2, with comparison of quantitative inferences between causal and association analyses; and 4) to create a DNA specimen bank for future studies of the role of genes potentially involved in determining susceptibility of asthmatic individuals to short and long-term effects of exposures to oxidant air pollutants and/or bioaerosols. The overall design is a series of panel studies embedded within a longitudinal cohort study. The 14-day panel studies include twice- daily spirometry and symptom evaluation. Longitudinal follow-up at annual field office visits includes a detailed questionnaire, classification of asthma severity, and pre- and post-bronchodilator spirometry. Data from the panel studies provide estimates of short-term responsiveness to ambient pollutants for each subject; the effect estimates for each panel are the principal "exposure" for the longitudinal analysis of asthma severity and lung function growth. The study has generated a unique body of detailed exposure and individual follow-up data that are otherwise not currently available. Strength is the use of statistical methods that address many limitations of previous studies. The results of the proposed study will contribute important information to the effort to control the burden of asthma through reductions in air pollution.

描述（由申请人提供）：为了解决重要的数据差​​距，我们建议继续一项纵向队列研究，即弗雷斯诺哮喘儿童环境研究（FACES），该研究由加利福尼亚空中资源委员会在过去5年中资助。该研究的总体目的是确定对短期反应不良的哮喘儿童是否每天增加环境空气污染物和生物溶质醇的浓度增加，更有可能增加长期的哮喘发病率和肺功能降低。该研究的具体目的是：1）评估暴露于空气污染物/生物杂色的长期健康影响对症状，哮喘严重程度和肺功能生长的长期健康影响； 2）评估与交通相关污染物和生物溶质的相互作用对短期和长期影响的影响； 3）使用新的因果分析方法（边际结构模型）来解决施舍1和2，并比较因果分析和关联分析之间的定量推断； 4）创建一个DNA标本库，用于将来研究潜在的基因在确定哮喘患者对氧化剂空气污染物和/或生物溶质的短期和长期影响的敏感性中的作用。总体设计是一系列嵌入在纵向队列研究中的小组研究。 14天的面板研究包括两次每日肺活量测定法和症状评估。年度野外办公室访问的纵向随访包括详细的问卷，哮喘严重程度的分类以及支气管缓解剂的肺活量测定法。小组研究的数据提供了每个受试者对环境污染物的短期响应性的估计；每个面板的效果估计值是哮喘严重程度和肺功能生长的纵向分析的主要“暴露”。该研究产生了独特的详细暴露和个人随访数据，否则这些数据当前尚不可用。强度是使用统计方法来解决以前研究的许多局限性。拟议研究的结果将为通过减少空气污染来控制哮喘负担的努力为重要信息提供重要的信息。