CENTER FOR DEVELOPMENT OF ANTI-SPERM CONTRACEPTIVES

抗精子避孕药开发中心

• 批准号: 7349724
• 负责人: PAUL PRIMAKOFF
• 金额: $ 4.97万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349724
• 关键词: CENTER; DEVELOPMENT; ANTI; SPERM; CONTRACEPTIVES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The focus of this Center is the gamete as a contraceptive target. Remarkable advances have occurred recently in genomics and proteomics, cell biology, fertilization research and drug discovery. These advances have combined to open new possibilities for contraceptive intervention, directed against gametes, that may have been previously imagined but were unattainable. Most of our projects target sperm, though one project proposes a potential egg target. Anti-sperm contraception can block sperm function or sperm development. Our Center's projects include both targets. A major theme of the Center is small molecule inhibitors to block sperm function. Our Center is actively studying sperm plasma membrane proteins that function in sperm-egg interaction and we propose screens for small molecules that inhibit these sperm proteins and thus prevent fertilization. A second theme is to block sperm development. Novel pharmacological strategies to derail the complex process of sperm production are proposed here. All of us who study sperm development are aware of important advances in spermatogenesis and realize that new, feasible contraceptive targets are being identified. Thus, we have proposed an expansion of our target list in spermatogenesis, increasing our scope and chances of developing new products for birth control.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。目的：该中心的重点是配子作为避孕目标。在基因组学和蛋白质组学，细胞生物学，受精研究和药物发现中，最近发生了显着进步。这些进步已经结合在一起，为针对配子的避孕干预措施开辟了新的可能性，这可能是以前想象的，但是无法实现的。我们的大多数项目都针对精子，尽管一个项目提出了潜在的鸡蛋靶标。抗植物避孕可以阻止精子功能或精子发育。我们中心的项目包括两个目标。该中心的主要主题是小分子抑制剂以阻断精子功能。我们的中心正在积极研究在精子相互作用中起作用的精子质膜蛋白，我们建议针对抑制这些精子蛋白的小分子进行筛选，从而防止受精。第二个主题是阻止精子开发。这里提出了新型的药理学策略，以使精子生产的复杂过程脱轨。我们所有研究精子发展的人都意识到精子发生的重要进展，并意识到正在确定新的，可行的避孕靶标。因此，我们建议在精子发生中扩展目标清单，从而增加我们开发新产品进行节育的范围和机会。