CENTER FOR DEVELOPMENT OF ANTI-SPERM CONTRACEPTIVES

抗精子避孕药开发中心

• 批准号: 7562211
• 负责人: PAUL PRIMAKOFF
• 金额: $ 5.74万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562211
• 关键词: Cell membrane; Cellular biology; Complex; Computer Retrieval of Information on Scientific Projects Database; Contraceptive Agents; Contraceptive methods; Development; Fertilization; Funding; Genomics; Germ Cells; Grant; Institution; Intervention; Membrane Proteins; Process; Production; Proteomics; Research; Research Personnel; Resources; Source; Sperm-Ovum Interactions; Spermatogenesis; United States National Institutes of Health; birth control; contraceptive target; drug discovery; egg; inhibitor/antagonist; novel; prevent; protein function; small molecule; sperm cell; sperm function; sperm protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The focus of this Center is the gamete as a contraceptive target. Remarkable advances have occurred recently in genomics and proteomics, cell biology, fertilization research and drug discovery. These advances have combined to open new possibilities for contraceptive intervention, directed against gametes, that may have been previously imagined but were unattainable. Most of our projects target sperm, though one project proposes a potential egg target. Anti-sperm contraception can block sperm function or sperm development. Our Center's projects include both targets. A major theme of the Center is small molecule inhibitors to block sperm function. Our Center is actively studying sperm plasma membrane proteins that function in sperm-egg interaction and we propose screens for small molecules that inhibit these sperm proteins and thus prevent fertilization. A second theme is to block sperm development. Novel pharmacological strategies to derail the complex process of sperm production are proposed here. All of us who study sperm development are aware of important advances in spermatogenesis and realize that new, feasible contraceptive targets are being identified. Thus, we have proposed an expansion of our target list in spermatogenesis, increasing our scope and chances of developing new products for birth control.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：该中心的重点是配子作为避孕目标。最近，基因组学和蛋白质组学、细胞生物学、受精研究和药物发现领域取得了显着进展。这些进步结合起来，为针对配子的避孕干预开辟了新的可能性，这可能是以前想象过但无法实现的。我们的大多数项目都以精子为目标，但有一个项目提出了潜在的卵子目标。抗精子避孕药可以阻止精子功能或精子发育。我们中心的项目包括这两个目标。该中心的一个主要主题是阻止精子功能的小分子抑制剂。我们的中心正在积极研究在精卵相互作用中发挥作用的精子质膜蛋白，我们建议筛选抑制这些精子蛋白从而阻止受精的小分子。第二个主题是阻止精子发育。本文提出了破坏精子产生复杂过程的新药理学策略。我们所有研究精子发育的人都意识到精子发生的重要进展，并意识到新的、可行的避孕目标正在被确定。因此，我们建议扩大精子发生的目标清单，扩大我们开发节育新产品的范围和机会。