PROLACTIN LEVELS PREDICT RELATIONSHIP QUALITY

催乳素水平可预测关系质量

• 批准号: 7349421
• 负责人: Charles T. Snowdon
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349421
• 关键词: PROLACTIN; LEVELS; PREDICT; RELATIONSHIP; QUALITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To assess whether prolactin, commonly thought to be important in parent-offspring relationships is also important in relationships between mates. Prolactin is necessary for successful nursing in mammals, and also regulates maternal behavior. In some biparental species of birds and mammals prolactin levels are elevated in fathers, and there is some evidence that prolactin may be important for quality male care of infants. Prolactin, thus, is often thought of as a "parental" hormone. Are there other conditions where elevated prolactin might be important? Parental care represents one type of social relationship, and prolactin might, therefore, be important in other social lationships. We have investigated the role of prolactin in paired female cotton-top tamarins and found significant positive correlations between prolactin levels and affiliative behavior (huddle, groom), sexual behavior and aggression. Females that were engaged in more social interactions with their mates had higher prolactin levels. A replication of this study looked at both sexes and found similar results for males and females. We replicated both of these studies to examine the causal relationship between affiliation and prolactin by administering cabergoline a dopamine agonist that reduces prolactin levels. Cabergoline did not alter affiliative behavior, but at the same time the control condition did not replicate our previous studies by correlating with prolactin levels. However, we did replicate the finding that there is great variation in relationship quality among different pairs. We are exploring whether other hormones associated with affiliation such as vasopressin and oxytocin will relate to realtionship quality. This work relied on the WNPRC Assay Services and Library and Information Services.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。评估催乳素（通常被认为在亲子关系中很重要）在伴侣关系中是否也很重要。 催乳素对于哺乳动物的成功哺乳是必需的，并且还调节母亲的行为。在一些双亲鸟类和哺乳动物中，父亲的催乳素水平升高，并且有一些证据表明催乳素对于男性婴儿的优质护理可能很重要。因此，催乳素通常被认为是“父母”激素。在其他情况下，催乳素升高是否可能很重要？父母的照顾代表了一种社会关系，因此催乳素可能在其他社会关系中很重要。我们研究了催乳素在配对雌性棉顶狨猴中的作用，发现催乳素水平与亲和行为（拥抱、新郎）、性行为和攻击性之间存在显着的正相关关系。与伴侣进行更多社交互动的女性催乳素水平更高。这项研究的重复性对两性进行了观察，发现男性和女性的结果相似。我们重复了这两项研究，通过给予卡麦角林（一种降低催乳素水平的多巴胺激动剂）来检查隶属关系和催乳素之间的因果关系。卡麦角林并没有改变亲和行为，但同时对照条件并没有通过与催乳素水平相关来复制我们之前的研究。然而，我们确实重复了这一发现，即不同配对之间的关​​系质量存在很大差异。我们正在探索与亲密关系相关的其他激素（例如加压素和催产素）是否与关系质量有关。这项工作依赖于 WNPRC 检测服务以及图书馆和信息服务。