PROLACTIN LEVELS PREDICT RELATIONSHIP QUALITY

催乳素水平可预测关系质量

• 批准号: 7349421
• 负责人: Charles T. Snowdon
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349421
• 关键词: PROLACTIN; LEVELS; PREDICT; RELATIONSHIP; QUALITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To assess whether prolactin, commonly thought to be important in parent-offspring relationships is also important in relationships between mates. Prolactin is necessary for successful nursing in mammals, and also regulates maternal behavior. In some biparental species of birds and mammals prolactin levels are elevated in fathers, and there is some evidence that prolactin may be important for quality male care of infants. Prolactin, thus, is often thought of as a "parental" hormone. Are there other conditions where elevated prolactin might be important? Parental care represents one type of social relationship, and prolactin might, therefore, be important in other social lationships. We have investigated the role of prolactin in paired female cotton-top tamarins and found significant positive correlations between prolactin levels and affiliative behavior (huddle, groom), sexual behavior and aggression. Females that were engaged in more social interactions with their mates had higher prolactin levels. A replication of this study looked at both sexes and found similar results for males and females. We replicated both of these studies to examine the causal relationship between affiliation and prolactin by administering cabergoline a dopamine agonist that reduces prolactin levels. Cabergoline did not alter affiliative behavior, but at the same time the control condition did not replicate our previous studies by correlating with prolactin levels. However, we did replicate the finding that there is great variation in relationship quality among different pairs. We are exploring whether other hormones associated with affiliation such as vasopressin and oxytocin will relate to realtionship quality. This work relied on the WNPRC Assay Services and Library and Information Services.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。评估催乳素（通常认为在父母之间的关系中很重要）是否在伴侣之间的关系中也很重要。 催乳素对于在哺乳动物中成功护理是必要的，并且还调节母性行为。在某些两种鸟类和哺乳动物的两种种类中，催乳素水平在父亲中升高，并且有证据表明催乳素对于婴儿的优质男性护理可能很重要。因此，催乳素通常被认为是一种“父母”激素。是否还有其他条件可能很重要？父母的护理代表一种社会关系，因此，催乳素在其他社会关系中可能很重要。我们已经研究了催乳素在配对的雌性棉ta菜蛋白中的作用，并发现催乳素水平与从属行为（Huddle，Groom），性行为和攻击性之间存在显着的正相关。与伴侣进行更多社交互动的女性具有较高的催乳素水平。这项研究的复制介绍了两性，并发现了男性和女性的类似结果。我们复制了这两项研究，以检查隶属关系和催乳素之间的因果关系，通过给cabergoline a多巴胺激动剂降低催乳素水平。 Cabergoline并没有改变从属行为，但与此同时，控制条件并未通过与催乳素水平相关的情况来复制我们以前的研究。但是，我们确实复制了以下发现，即不同对之间的关​​系质量存在很大差异。我们正在探索与加压素和催产素等隶属关系相关的其他激素是否与房地产质量有关。这项工作依赖于WNPRC分析服务以及图书馆和信息服务。