Smart Lidocaine Gels for Pain Management

用于疼痛管理的智能利多卡因凝胶

• 批准号: 7273098
• 负责人: Chirakkal Krishnan
• 金额: $ 21.33万
• 依托单位: STONYBROOK TECHNOLOGY/APPLIED RESEARCH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7273098
• 关键词: Affect; Alginates; Anesthetics; Animal Testing; Applied Research; Behavior; Biomedical Engineering; Body Temperature; Characteristics; Chitosan; Class; Complex; Drug Delivery Systems; Ethylene Oxide; Gel; In Vitro; Injection of therapeutic agent; Injury; Laboratories; Lasers; Lead; Lidocaine; Life; Local Anesthetics; Marketing; Methods; Microscopic; Modeling; Nanostructures; Nanotechnology; Pain; Pain management; Pathway interactions; Performance; Pharmaceutical Preparations; Phase; Phase Transition; Physiological; Pluronics; Property; Range; Rattus; Relative (related person); Research; Roentgen Rays; Site; System; Tail; Techniques; Technology; Testing; Therapeutic; Time; Treatment Efficacy; United States National Institutes of Health; Water; Week; base; chronic pain; controlled release; copolymer; day; design; dosage; in vivo; light scattering; nanostructured; particle; poly(propylene oxide); pressure; programs; self assembly; size; submicron

DESCRIPTION (provided by applicant): This Phase I proposal aims to develop a unique class of nanostructured smart lidocaine gels for site-specific pain management. The hypothesis for the design and testing of this gel system is based on two recent findings. (1) Medicated smart gels, containing lidocaine (an anesthetic drug) and mixtures of pluronic-based block copolymers (poly (ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)) in water, can be fine-tuned by copolymer composition and concentration to possess thermo reversible gelation behavior near the body temperature. Such characteristics will enable the sustained and controlled release of lidocaine molecules and can facilitate site deployment pathways (e.g. low pressure spraying, injection or topical coating). (2) The dynamic formation of microscopic bioabsorbable medicated particles (micron and submicron sizes) based on polyelectrolyte complex formation (e.g., mixtures based on chitosan and alginate) can provide a sustained release of lidocaine to tens of days. To test the above hypothesis, three specific aims have been proposed to verify the scientific merits and technical feasibility of the approach. Specific Aim 1: Characterize and optimize therapeutic mixtures of lidocaine-pluronic smart gels and lidocaine containing polyelectrolyte complex particles with sustained lidocaine release capability (from days to weeks or perhaps even months). Specific Aim 2: In vitro assessments of the therapeutic efficacies of mixtures of lidocaine-pluronic smart gels, lidocaine-containing polyelectrolyte complex particles, and smart gels containing such complex particles. Specific Aim 3: Determination of the relative in vivo efficacies of lidocaine-containing smart gels by using two rat models based on the hot-plate test and the tail-flick test. The strength of the proposed system is its ability to manage pain through controlled and sustained release of local anesthetics at the injury site. The persistence of chronic pain can affect many different aspects of personal life, ranging from the physiological to societal and financial changes. This proposal aims to develop a unique class of smart lidocaine gels for pain management. The strength of the proposed system is its ability to manage pain through controlled and sustained release of local anesthetics at the injury site.

描述（由申请人提供）：该第一阶段提案旨在开发一类独特的纳米结构智能利多卡因凝胶，用于特定部位的疼痛管理。该凝胶系统的设计和测试假设基于两项最近的发现。 (1) 含药智能凝胶，含有利多卡因（一种麻醉药）和普朗尼克基嵌段共聚物（聚（环氧乙烷）-b-聚（环氧丙烷）-b-聚（环氧乙烷））在水中的混合物，可以通过共聚物组成和浓度进行微调，以在接近体温时具有热可逆凝胶行为。这些特性将实现利多卡因分子的持续和受控释放，并可以促进位点部署途径（例如低压喷雾、注射或局部涂覆）。 (2)基于聚电解质复合物形成(例如，基于壳聚糖和藻酸盐的混合物)动态形成微观生物可吸收含药颗粒(微米和亚微米尺寸)，可以提供利多卡因长达数十天的持续释放。为了检验上述假设，提出了三个具体目标来验证该方法的科学优点和技术可行性。具体目标 1：表征和优化利多卡因-普朗尼克智能凝胶和含有利多卡因的聚电解质复合颗粒的治疗混合物，具有持续利多卡因释放能力（几天到几周甚至几个月）。具体目标2：利多卡因-普朗尼克智能凝胶、含利多卡因的聚电解质复合颗粒和包含此类复合颗粒的智能凝胶的混合物的治疗功效的体外评估。具体目标 3：基于热板试验和甩尾试验，使用两种大鼠模型确定含利多卡因的智能凝胶的相对体内功效。该系统的优点在于它能够通过在受伤部位控制和持续释放局部麻醉剂来控制疼痛。慢性疼痛的持续存在会影响个人生活的许多不同方面，从生理到社会和经济变化。该提案旨在开发一种独特的智能利多卡因凝胶用于疼痛管理。该系统的优点在于它能够通过在受伤部位控制和持续释放局部麻醉剂来控制疼痛。