Functional Microcircuitry of Corticostriatal Projections

皮质纹状体投射的功能微电路

• 批准号: 7274804
• 负责人: Mark Nathaniel Miller
• 金额: $ 2.72万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7274804
• 关键词: Address; Behavior; Cells; Class; Corpus striatum structure; Data; Disease; Exhibits; Fellowship; Functional disorder; Huntington Disease; Individual; Interneurons; Membrane; Morphology; Motor Cortex; Movement; Myoepithelial cell; Names; Neurosciences; Numbers; Pathology; Pathway interactions; Population; Population Distributions; Process; Property; Pyramidal Cells; Pyramidal Tracts; Recurrence; Role; Shapes; Specificity; Structure; Testing; Time; cell type; insight; nerve supply; nervous system disorder; neuropathology; research study; theories

DESCRIPTION (provided by applicant): The striatum is critically involved in the planning and execution of directed movement, and numerous neurological disorders are closely associated with striatal dysfunction. Despite a detailed understanding of striatal cellular and circuit function, and compelling evidence that striatal function is to a large extent governed by highly structured corticostriatal input, the intracortical mechanisms responsible for shaping and providing this input remain unknown. I propose to elucidate these mechanisms by characterizing the intrinsic membrane properties and morphologies of the two major corticostriatal layer V pyramidal populations, determine whether they, like some other pyramidal cell classes, form subnetworks of preferential homotypic connections, and whether they are subject to differential local inhibition. Results from these experiments will not only clarify the cortical determinants of corticostriatal activity but, by asking whether functionally related layer V pyramidal cells form distinct or overlapping local networks, will also provide insight into the principles of cortical circuit organization.

描述（由申请人提供）：纹状体与定向运动的计划和执行至关重要，并且许多神经系统疾病与纹状体功能障碍密切相关。尽管对纹状体细胞和电路功能有详细的了解，并且令人信服的证据表明，纹状体功能在很大程度上受到高度结构化皮质纹状体输入的影响，但导致塑造和提供此输入的物质内机制仍然未知。我建议通过表征两个主要皮质层状层V锥体种群的固有膜特性和形态来阐明这些机制，确定它们是否像其他一些金字塔细胞类别一样，形成了优先型型连接的子网，以及它们是否受到局部局部抑制作用。这些实验的结果不仅会阐明皮质纹状体活性的皮质决定因素，而且还通过询问功能相关的层V锥体细胞是否形成不同的局部网络或重叠的局部网络，还将洞悉皮质电路组织的原理。