Functional Microcircuitry of Corticostriatal Projections

皮质纹状体投射的功能微电路

• 批准号: 7154959
• 负责人: Mark Nathaniel Miller
• 金额: $ 2.72万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7154959
• 关键词: fasting; pyramidal cells

DESCRIPTION (provided by applicant): The striatum is critically involved in the planning and execution of directed movement, and numerous neurological disorders are closely associated with striatal dysfunction. Despite a detailed understanding of striatal cellular and circuit function, and compelling evidence that striatal function is to a large extent governed by highly structured corticostriatal input, the intracortical mechanisms responsible for shaping and providing this input remain unknown. I propose to elucidate these mechanisms by characterizing the intrinsic membrane properties and morphologies of the two major corticostriatal layer V pyramidal populations, determine whether they, like some other pyramidal cell classes, form subnetworks of preferential homotypic connections, and whether they are subject to differential local inhibition. Results from these experiments will not only clarify the cortical determinants of corticostriatal activity but, by asking whether functionally related layer V pyramidal cells form distinct or overlapping local networks, will also provide insight into the principles of cortical circuit organization.

描述（由申请人提供）：纹状体对于定向运动的计划和执行至关重要，并且许多神经系统疾病与纹状体功能障碍密切相关。尽管对纹状体细胞和回路功能有了详细的了解，并且有令人信服的证据表明纹状体功能在很大程度上受到高度结构化的皮质纹状体输入的控制，但负责塑造和提供这种输入的皮质内机制仍然未知。我建议通过表征两个主要皮质纹状体层 V 锥体细胞群的内在膜特性和形态来阐明这些机制，确定它们是否像其他一些锥体细胞类别一样形成优先同型连接的子网络，以及它们是否受到局部差异的影响。抑制。这些实验的结果不仅将阐明皮质纹状体活动的皮质决定因素，而且通过询问功能相关的第五层锥体细胞是否形成不同或重叠的局部网络，还将深入了解皮质回路组织的原理。