Race, Obesity and Enteroinsular Axis in Adolescents

青少年的种族、肥胖和肠岛轴

• 批准号: 7257223
• 负责人: PEDRO A VELASQUEZ-MIEYER
• 金额: $ 13.62万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-22 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7257223
• 关键词: Accounting; Adolescent; Affect; African American; Age; American; Area; Autonomic nervous system; Award; Bioinformatics; C-Peptide; Calories; Cardiovascular Diseases; Cells; Childhood; Clinical; Comorbidity; Data; Dietary intake; Disease; Dual-Energy X-Ray Absorptiometry; Equilibrium; Exercise; Fatty acid glycerol esters; Food; Foundations; Gender; Glucose; Goals; Heart Rate; Holter Electrocardiography; Homocysteine; Homocystine; Inflammatory; Insulin; Intake; Knowledge; Life Style; Lipids; Lipoproteins; Low-Density Lipoproteins; Macronutrients Nutrition; Measurement; Measures; Medical; Methodology; Minority Groups; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Obesity; Overweight; Oxygen Consumption; Particle Size; Pathway interactions; Pharmacoepidemiology; Prevalence; Preventive Medicine; Race; Range; Records; Recruitment Activity; Research Personnel; Risk Factors; Sampling; Severities; Specific qualifier value; Training; Translating; Translational Research; Treatment outcome; Youth; base; blood glucose regulation; cardiovascular disorder risk; career; day; experience; fitness; glucagon-like peptide 1; indexing; insulin secretion; interest; lipid biosynthesis; obesity treatment; patient oriented; programs; racial difference; response; skills

My career goals are focused upon two concurrent diseases, childhood obesity and type 2 diabetes mellitus, affecting prominently adolescents of minority groups. Identifying new etiopathogenic mechanisms that explain the racial disparity and the potential influence of racial and lifestyle factors on predicting treatment outcomes are my long-term goals. With this focus, I am commited to patient-oriented translational research but I need to acquire specific skills that allow me to be more effective in this area. This award will allow me to accomplish these goals in the following way. I will: 1) enhance my statistical and epidemiological foundation; 2) develop skills in methodology, measurements, and analysis of epidemiological data; 3) develop the neccesary knowledge in preventive medicine, pharmacoepidemiology and bioinformatics necessary for implementing interventional studies based on the experience gained in my training and the )reliminary results of the proposed project. In obese African American (AA) subjects, we have proposed that ncreased GLP-1 levels [marker of enteroinsular axis activity (EIA) ] could promote adipogenesis and the :levelopment of comorbidities. It is still unclear whether these racial differences in EIA are determined by age, severity of overweight, differences in cardiorespiratory fitness (CRF) or autonomic nervous system (ANS) modulation. We will assess these three interrelated areas (EIA, CRF, and ANS modulation) in a bi- racial sample of wide-ranging overweight adolescents. In particular, we are interested in the relation between EIA activity and insulin dynamics as a potential mechanistic pathway to explain the increased prevalence of obesity, type 2 Diabetes Mellitus (T2DM) and Cardiovascular Disease (CVD)in AA youth. ITherefore, we will determine the associations among EIA, CRF, glucose homeostasis, and risk factors for ICVD in adolescents. The results of this study can be translated into medical practice changes and may help to implement a more physiologically effective approach to obesity treatment in AA adolescents, in particular.

我的职业目标集中在两种并发疾病：儿童肥胖症和 2 型糖尿病， 对少数群体青少年的影响尤为显着。确定新的致病机制 解释种族差异以及种族和生活方式因素对预测治疗的潜在影响 结果是我的长期目标。以此为重点，我致力于以患者为中心的转化研究 但我需要获得特定的技能，让我在这个领域更加有效。这个奖项将使我 通过以下方式实现这些目标。我将：1）增强我的统计和流行病学能力 基础; 2) 培养流行病学数据的方法、测量和分析技能； 3） 发展预防医学、药物流行病学和生物信息学的必要知识 根据我在培训中获得的经验和实施干预研究所必需的 ）拟议项目的初步结果。在肥胖的非洲裔美国人 (AA) 受试者中，我们建议 增加 GLP-1 水平 [肠岛轴活性 (EIA) 标志物] 可以促进脂肪生成和 ：合并症的水平。目前尚不清楚 EIA 中的这些种族差异是否是由 年龄、超重严重程度、心肺健康 (CRF) 或自主神经系统的差异 （ANS）调制。我们将以双向方式评估这三个相互关联的领域（EIA、CRF 和 ANS 调制） 广泛超重青少年的种族样本。我们特别感兴趣的是这种关系 EIA 活动和胰岛素动力学之间作为解释增加的潜在机制途径 AA 青年中肥胖、2 型糖尿病 (T2DM) 和心血管疾病 (CVD) 的患病率。 因此，我们将确定 EIA、CRF、葡萄糖稳态和危险因素之间的关联 青少年 ICVD。这项研究的结果可以转化为医疗实践的改变，并可能有所帮助 尤其是对 AA 青少年实施一种生理上更有效的肥胖治疗方法。