Race, Obesity and Enteroinsular Axis in Adolescents

青少年的种族、肥胖和肠岛轴

• 批准号: 6863827
• 负责人: PEDRO A VELASQUEZ-MIEYER
• 金额: $ 13.46万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-22 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6863827
• 关键词: African American; adolescence (12-20); autonomic nervous system; blood chemistry; body composition; cardiovascular disorder risk; caucasian American; clinical research; diabetes risk; glucose tolerance test; health disparity; heart rate; hormone regulation /control mechanism; human subject; incretin hormone; insulin; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; obesity; oxygen consumption; pancreatic islet function; patient oriented research; photon absorptiometry; physical fitness; racial /ethnic difference

DESCRIPTION (provided by applicant): My career goals are focused upon two concurrent diseases, childhood obesity and type 2 diabetes mellitus, affecting prominently adolescents of minority groups. Identifying new etiopathogenic mechanisms that explain the racial disparity and the potential influence of racial and lifestyle factors on predicting treatment outcomes are my long-term goals. With this focus, I am committed to patient-oriented translational research but I need to acquire specific skills that allow me to be more effective in this area. This award will allow me to accomplish these goals in the following way. I will: 1) enhance my statistical and epidemiological foundation; 2) develop skills in methodology, measurements, and analysis of epidemiological data; 3) develop the necessary knowledge in preventive medicine, pharmacoepidemiology and bioinformatics necessary for implementing interventional studies based on the experience gained in my training and the preliminary results of the proposed project. In obese African-American (AA) subjects, we have proposed that increased GLP-1 levels [marker of enteroinsular axis activity (EIA)] could promote adipogenesis and the development of comorbidities. It is still unclear whether these racial differences in EIA are determined by age, severity of overweight, differences in cardiorespiratory fitness (CRF) or autonomic nervous system (ANS) modulation. We will assess these three interrelated areas (EIA, CRF, and ANS modulation) in a biracial sample of wide-ranging overweight adolescents. In particular, we are interested in the relation between EIA activity and insulin dynamics as a potential mechanistic pathway to explain the increased prevalence of obesity, type 2 Diabetes Mellitus (T2DM) and Cardiovascular Disease (CVD) in AA youth. Therefore, we will determine the associations among EIA, CRF, glucose homeostasis, and risk factors for ICVD in adolescents. The results of this study can be translated into medical practice changes and may help to implement a more physiologically effective approach to obesity treatment in AA adolescents, in particular.

描述（由申请人提供）： 我的职业目标集中于两种并发疾病：儿童肥胖症和 2 型糖尿病，这两种疾病对少数群体青少年的影响尤为显着。确定新的病因机制来解释种族差异以及种族和生活方式因素对预测治疗结果的潜在影响是我的长期目标。以此为重点，我致力于以患者为导向的转化研究，但我需要获得特定的技能，使我能够在这一领域更加有效。这个奖项将使我能够通过以下方式实现这些目标。我将：1）增强我的统计和流行病学基础； 2) 培养流行病学数据的方法、测量和分析技能； 3）根据我在培训中获得的经验和拟议项目的初步结果，培养实施介入研究所需的预防医学、药物流行病学和生物信息学方面的必要知识。在肥胖的非洲裔美国人 (AA) 受试者中，我们提出增加 GLP-1 水平 [肠岛轴活动 (EIA) 标志物] 可以促进脂肪形成和合并症的发展。目前尚不清楚 EIA 中的这些种族差异是否由年龄、超重严重程度、心肺健康 (CRF) 或自主神经系统 (ANS) 调节的差异决定。我们将在广泛的超重青少年的混血儿样本中评估这三个相互关联的领域（EIA、CRF 和 ANS 调节）。我们特别感兴趣的是 EIA 活动和胰岛素动态之间的关系，作为解释 AA 青少年中肥胖、2 型糖尿病 (T2DM) 和心血管疾病 (CVD) 患病率增加的潜在机制途径。因此，我们将确定青少年 EIA、CRF、葡萄糖稳态和 ICVD 危险因素之间的关联。这项研究的结果可以转化为医疗实践的改变，并可能有所帮助 尤其是对 AA 青少年实施一种生理上更有效的肥胖治疗方法。