PSYCHOSOCIAL RISK FOR CARDIOVASCULAR DISEASE IN YOUTH

青少年心血管疾病的社会心理风险

• 批准号: 6344951
• 负责人: ADRIAN C ANGOLD
• 金额: $ 27.36万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6344951
• 关键词: African American; Native Americans; adolescence (12-20); aggression; angers; attitude; autonomic nervous system; behavioral /social science research tag; behavioral medicine; cardiovascular disorder; child (0-11); child rearing; clinical research; depression; disease /disorder proneness /risk; human puberty; human subject; isolation /deprivation; longitudinal human study; low socioeconomic status; socioenvironment

The aim of the Psychosocial Risk for Cardiovascular Disease in Youth Project (PRCVDYP) is to use three ongoing general population studies of youth as basis for examining the development of psychosocial risk for CVD. In relation to the Program Project as a whole, the PRCVDYP will address and expand upon Programmatic Objective 2 in examining the questions of whether and how harsh environments in childhood and adolescence (e.g., poverty and negative parenting styles) lead to negative psychosocial risk profiles (hostility, depression, and social isolation), and in turn whether and how such psychosocial risks translate into more proximal risks for CVD (heart rate and blood pressure indicaes, adiposity, smoking and alcohol use). We will use (a) ethnically diverse, (b) representative general population samples aged 9 - 16 and their parents to study (c) cross-generational predicators of (d) multiple components of (e) hostility, (f) depression and (g) social isolation, (h) over repeated waves of measurement. We will pay particular attention to the possibility that (1) different patterns of risk evolve in males and females at (j) puberty. The PRCVDYP builds on three current, NIH-funded studies: The Great Smoky Mountains Study (GSMS), a longitudinal study of risk for psychiatric disorder in a representative population-based sample of 1,072 youth in western North Carolina; The American Indian Study (AIS), which uses the same design and methods to study 354 American Indian (Cherokee) youth from the same geographic area as the GSMS; and Caring for Children in the Community Study (CCCS), a similar study of 1,200 youth set in an area of eastern North Carolina where 50 percent of the population are African American. In each sample, approximately 50 percent are female. Socio-economic status, social adversity, social isolation, depression, weight, height, pubertal status (morphological and hormonal), family functioning, and harsh parenting style are measured in these studies over three waves of data collection. Funds are requested to add to the ongoing studies in the following ways: 1. to analyze the audiotapes of the GSMS, AIS and CCCS interviews of parents and children, using the interpersonal Hostility Assessment Technique (IHAT), which uses vocal stylistics to assess underlying hostility; 2. to administer the Cook-Medley Hostility Scale to assess cynical, angry and aggressive attitudes in 800 parents and youth from the CCCS; 3. to assess SNS and PNS tone and reactivity to physical (assuming upright posture) and mental (attentional task) challenges to 800 youth from the CCCS; and 4. to repeat all three additional studies in two follow-up waves of 180 youth from the CCCS sample, selected for being at high and low CVD risk. We hypothesize that (1) low SES youth will wxhibit, in addition to increased levels of the psychosocial and behavioral risk factors under study, increased SNS tone and reactivity to mental challenge, as well as decreased INS tone; (2) Depression, social isolation, and harsh parenting will interact with low SES to increase CVD risk.

青少年心血管疾病的心理社会风险的目的 项目（PRCVDYP）将利用三项正在进行的一般人群研究 作为检查社会心理风险发展的基础 用于CVD。 就整个计划项目而言，PRCVDYP 将解决并扩展规划目标 2，审查 童年时期的环境是否恶劣以及有多恶劣的问题 青春期（例如贫困和消极的养育方式）导致 负面心理社会风险状况（敌意、抑郁和社交 隔离），以及这种心理社会风险是否以及如何风险 转化为更近端的 CVD 风险（心率和血液 压力指标、肥胖、吸烟和饮酒）。 我们将使用 (a) 种族多样化，(b) 具有代表性的一般人群样本 9-16岁及其父母学习（三）跨代 (d) (e) 敌意、(f) 抑郁的多个组成部分的预测因素 (g) 社会隔离，(h) 反复测量。 我们 将特别注意 (1) 不同的可能性 (j) 青春期男性和女性的风险模式演变。 PRCVDYP 建立在 NIH 资助的三项当前研究的基础上： 大烟山研究 (GSMS)，一项针对风险的纵向研究 具有代表性的人群样本中的精神疾病 北卡罗来纳州西部 1,072 名青少年；美洲印第安人研究（AIS）， 使用相同的设计和方法来研究 354 名美洲印第安人 来自与 GMS 同一地理区域的（切罗基）青年；和关怀 社区儿童研究 (CCCS)，一项针对 1,200 名儿童的类似研究 青年生活在北卡罗来纳州东部的一个地区，那里 50% 的人 人口是非裔美国人。 每个样本中大约有 50 % 为女性。 社会经济地位、社会逆境、社会 孤立、抑郁、体重、身高、青春期状态（形态学） 和荷尔蒙）、家庭功能和严厉的养育方式 这些研究通过三波数据收集进行了测量。 请求资金添加到以下正在进行的研究中 方式： 1. 分析GSMS、AIS和CCCS访谈录音带 父母和孩子的关系，使用人际敌意评估 技术 (IHAT)，使用声音风格来评估潜在的 敌意; 2. 使用 Cook-Medley 敌意量表进行评估 来自 800 名家长和青少年的愤世嫉俗、愤怒和攻击性态度 CCCS； 3. 评估 SNS 和 PNS 音调以及对身体的反应性 （假设直立姿势）和精神（注意力任务）挑战 800名CCCS青年； 4. 重复所有三项额外研究 在后续两轮中，从 CCCS 样本中选取了 180 名青年， CVD 风险高和低。 我们假设 (1) 社会经济地位低的年轻人除了 社会心理和行为危险因素水平增加 研究，增加了 SN​​S 语气和对精神挑战的反应性，以及 INS 音调降低； (2) 抑郁、社会孤立和严酷 养育子女会与低社会经济地位相互作用，从而增加 CVD 风险。