Quantitative Mass Spectrometry

定量质谱分析

• 批准号: 7328423
• 负责人: Kenneth Tomer
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7328423
• 关键词: Quantitative; Mass; Spectrometry

Quantitative Mass Spectrometry incorporates collaborative projects in which the Mass Spectrometry Group provides quantitative information about, typically, small molecules by GC/MS, LC/MS and LC/MS/MS or a combination. An example of the types of projects this includes is the isoprostane analyses undertaken as part of the NIEHS led study of biomarkers of oxidative stress. We currently have three major collaborations underway: 1) with Darryl Zeldin on Atherosclerosis Risk In Communities (ARIC) Ancillary Study; 2) with James Mohler on Interference with the Androgen Receptor and its Ligands in Recurrent Prostate Cancer; and 3) with Ron Cannon on fatty acid profile differences in a mutant mouse strain compared to wild type.

定量质谱法结合了协作项目，其中质谱组提供了有关GC/MS，LC/MS和LC/MS/MS或组合的定量信息，通常是针对小分子的定量信息。其中包括的项目类型的一个例子是作为NIEHS LED氧化应激生物标志物研究的一部分进行的异丙烷分析。目前，我们正在进行三项主要合作：1）与达里尔·塞尔丁（Darryl Zeldin）有关社区（ARIC）辅助研究的动脉粥样硬化风险； 2）与詹姆斯·莫勒（James Mohler）干扰了复发性前列腺癌中的雄激素受体及其配体； 3）与野生型相比，突变小鼠菌株中的脂肪酸剖面差异与脂肪酸谱差异。