Exploring Sustainable Antibacterial Solutions for Personal Hygiene Products

探索个人卫生产品的可持续抗菌解决方案

• 批准号: 2894260
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2894260
• 关键词: Exploring; Sustainable; Antibacterial; Solutions; Personal

Antimicrobial agents including peptides and derivatives, molecular mechanisms, real-time visualization methods of bacterial growth inhibition, analytical measurements of surface interactions with bacteria, surface immobilization approach that is practical for industrial application, stability, and migration studies. This project focuses on studying the mechanisms of antibacterial fibre and nonwoven materials for application in personal hygiene products. Antimicrobial agents (AMA) can be peptides such as polylysine, nisin and defensin or derivatives with mode of actions varying from microbial cell membrane disruption to metabolic disruption. Antimicrobials of plant origin like Green Tea and Vitamin E are also of great interest for driving the synergy. As AMA needs to be robustly attached on fibre substrates to deliver durable performance and minimize migration risk, surface modification or grafting strategies enabling better immobilisation will be developed and evaluated for industrial scale-up feasibility. The scientific insights are expected to enable new material/technology developments that are ownable to the company. The project also aims to create and develop novel capabilities for visualizing/measuring the AMA-bacteria interactions in real time. Real application and aging conditions need to be factored in for supporting the projects in Baby/Fem Care business.

抗菌剂，包括肽和衍生物、分子机制、细菌生长抑制的实时可视化方法、与细菌表面相互作用的分析测量、适用于工业应用、稳定性和迁移研究的表面固定方法。该项目重点研究抗菌纤维和非织造材料在个人卫生用品中的应用机理。抗菌剂 (AMA) 可以是肽，例如聚赖氨酸、乳链菌肽和防御素或衍生物，其作用方式从微生物细胞膜破坏到代谢破坏不等。绿茶和维生素 E 等植物源抗菌剂对于推动协同作用也很有意义。由于 AMA 需要牢固地附着在纤维基材上，以提供持久的性能并最​​大限度地降低迁移风险，因此将开发和评估能够实现更好固定的表面改性或接枝策略，以实现工业规模扩大的可行性。科学见解预计将促进公司拥有的新材料/技术的开发。该项目还旨在创建和开发实时可视化/测量 AMA-细菌相互作用的新功能。为了支持婴儿/女性护理业务的项目，需要考虑实际应用和老化条件。