Metal Carcinogenesis: New Concepts

金属致癌：新概念

• 批准号: 7161256
• 负责人: Anatoly Zhitkovich
• 金额: $ 0.79万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-10 至 2007-07-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7161256
• 关键词: carcinogenesis; meeting /conference /symposium; metals; neoplasm /cancer; travel

DESCRIPTION (provided by applicant): This proposal requests financial support for a half-day symposium on "Metal Carcinogenesis: New Concepts" to be held during the American Chemical Society Annual Meeting in San Francisco, CA, on September 10-14, 2006. Several metals have long been known as human carcinogens; however, the mechanisms of their carcinogenicity remained elusive and in most cases, did not involve direct DNA damage or significant induction of mutagenesis. The field of metal carcinogenesis has recently experienced major advances due to identification of several reactive metal complexes, establishment of the importance of cellular metabolism in the formation of ultimate genotoxic species and discovery of co-carcinogenic potential of metals. These three emerging areas are the main topics of the symposium. The speakers were chosen based on their international reputation and scientific leadership in the formulation of the novel concepts in metal carcinogenesis. The main goal of this symposium is to present these new concepts to a broad scientific community and to identify research needs and future directions that would lead to further advances in the field of metal carcinogenesis and co-carcinogenesis.

说明（由申请人提供）：本提案请求为 2006 年 9 月 10 日至 14 日在加利福尼亚州旧金山举行的美国化学会年会期间举办的为期半天的“金属致癌：新概念”研讨会提供财政支持。几种金属长期以来一直被认为是人类致癌物；然而，它们的致癌机制仍然难以捉摸，并且在大多数情况下，不涉及直接的 DNA 损伤或显着诱导突变。由于几种活性金属络合物的鉴定、细胞代谢在最终基因毒性物质形成中重要性的确立以及金属协同致癌潜力的发现，金属致癌领域最近经历了重大进展。 这三个新兴领域是本次研讨会的主要议题。 发言人的选择是基于他们在金属致癌新概念的制定方面的国际声誉和科学领导力。 本次研讨会的主要目标是向广大科学界展示这些新概念，并确定研究需求和未来方向，从而推动金属致癌和协同致癌领域的进一步进展。