Medicinal Inorganic Chemistry ACS Symposium F-2003

药物无机化学 ACS 研讨会 F-2003

• 批准号: 6703453
• 负责人: Jonathan L Sessler
• 金额: $ 0.5万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6703453
• 关键词: chemistry; chromium; free radicals; ion transport; ions; meeting /conference /symposium; metalloproteins; metals; radionuclide imaging /scanning; travel; vanadium

DESCRIPTION (provided by applicant): Funds are requested to defray in part the travel, registration, and local expenses of participants in the Medicinal Inorganic Chemistry (MIC) symposium to be held at the Fall American Chemical Society (ACS) meeting in New York, NY, September 9-11, 2003. This symposium, the first of its kind, is sponsored jointly by the Inorganic Chemistry and the Medicinal Chemistry Divisions of the ACS. It is intended to extend and support the newly initiated set of Gordon Conferences of the same name (MIC-GRC) that were inaugurated at Colby-Sawyer College in July 2002 and which are planned for the same venue in July of 2004. As has been true for the MIC-GRC meetings, the purpose of the MIC-ACS symposium is to outline the state-of-the-art in the field, from drug design to development to clinical trials, present up-to-the-minute research on metal-containing systems of medical importance, and foster the formation of new collaborative research efforts in the field. However, the symposium is designed to have a higher teaching component and be substantially more inclusive than the GRC's. In particular, whereas, the MIC-GRC meetings are designed to bring together established experts for high level (and formally confidential) discussions, a prime goal of the present MIC-ACS symposium is to attract new researchers to the area and provide them with an understanding of what is needed to conduct research on metal-based pharmaceutical agents. Thus, unlike the MIC-GRC, the MIC-ACS symposium will feature a tutorial session designed to show what is necessary to bring a putative metal-based drug substance from the laboratory to the point of initial clinical trials. Specific topics to be emphasized in this symposium include 1) the role of metal-generated radicals in health and disease; 2) metalloproteins in health and disease; 3) metalloproteins as drug targets; 4) transport of metals and metal complexes; 5) magnetic resonance imaging agents; 6) metal ions, metal complexes and malaria; 7) radioimaging agents; 8) vanadium and chromium in health and disease and, 9) metal ion-nucleic acid interactions. This mixture of topics, which will be covered through a series of research lectures designed to complement the tutorial session, as well as through poster sessions. It is thus expected that the present MIC-ACS symposium will afford a unique opportunity to develop further growth in a field of study that is rich in opportunity and central to the NIH mission.

描述（由申请人提供）： 申请资金用于支付参加在纽约举行的美国化学会 (ACS) 秋季会议上举行的药物无机化学 (MIC) 研讨会的部分旅行、注册和当地费用，纽约，2003 年 9 月 9 日至 11 日。本次研讨会是此类研讨会的首次，由 ACS 无机化学部和药物化学部联合主办。它的目的是扩展和支持新发起的一系列同名戈登会议 (MIC-GRC)，这些会议于 2002 年 7 月在科尔比索耶学院举行，并计划于 2004 年 7 月在同一地点举行。与 MIC-GRC 会议一样，MIC-ACS 研讨会的目的是概述该领域的最新技术，从药物设计到开发再到临床试验，展示对具有医学重要性的含金属系统进行最新研究，并促进该领域新的合作研究工作的形成。然而，与 GRC 相比，该研讨会的教学内容更高，包容性也更强。特别是，虽然 MIC-GRC 会议旨在聚集知名专家进行高级别（且正式保密）讨论，但本次 MIC-ACS 研讨会的主要目标是吸引新研究人员进入该领域，并为他们提供了解进行金属药剂研究所需的条件。因此，与 MIC-GRC 不同，MIC-ACS 研讨会将以辅导会议为特色，旨在展示将假定的金属基药物从实验室带到初步临床试验的必要条件。本次研讨会重点讨论的具体议题包括：1）金属自由基在健康和疾病中的作用； 2）健康和疾病中的金属蛋白； 3）金属蛋白作为药物靶点； 4）金属和金属络合物的运输； 5) 磁共振成像剂； 6）金属离子、金属络合物与疟疾； 7) 放射显像剂； 8) 钒和铬在健康和疾病中的作用，9) 金属离子-核酸相互作用。这些主题的混合将通过一系列旨在补充教程课程的研究讲座以及海报会议来涵盖。因此，预计本次 MIC-ACS 研讨会将提供一个独特的机会，以进一步发展这一充满机会且对 NIH 使命至关重要的研究领域。

项目成果

Supramolecular receptor design: anion-triggered binding of C60.

超分子受体设计：阴离子触发的 C60 结合。

• 发表时间: 2006-10-20
• 作者: Nielsen, Kent A;Cho, Won;Sarova, Ginka H;Petersen, Bo M;Bond, Andrew D;Becher, Jan;Jensen, Frank;Guldi, Dirk M;Sessler, Jonathan L;Jeppesen, Jan O
• 通讯作者: Jeppesen, Jan O