Short Laboratory Courses in High Throughput Biolog(RMI)

高通量生物学 (RMI) 短期实验室课程

• 批准号: 7021682
• 负责人: Aydin Tozeren
• 金额: $ 15万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7021682
• 关键词: bioinformatics; biotechnology; computational biology; health science profession; high throughput technology; meeting /conference /symposium; nanotechnology; technology /technique; training; travel

DESCRIPTION (provided by applicant): Overall Purpose of the proposed project, GPBA Short Laboratory Courses in High Throughput Biology, is to develop an interdisciplinary workforce capable of crossing disciplinary boundaries across biology, nanotechnology and computer sciences. Such a workforce will further develop recently emerging fields such as bioinformatics and help create new interdisciplines involving computations in high throughput biomedicine. The instrument to be used for this purpose is the Greater Philadelphia Bioinformatics Alliance (GPBA), a consortium of regional research and academic organizations dedicated to advancing bioinformatics and computational biology-the integration of biology and advanced computation sciences that is revolutionizing life science research and holds the promise for significantly improved healthcare. By linking together the Philadelphia region's broad knowledge base of talented bioinformatics workers in academia, research institutions and the private sector, GPBA is working to provide new solutions to major medical, life sciences and environmental challenges. This grant requests support for eight-to-ten week session of sequential short laboratory courses in high throughput biology. The sequence is composed of following modules: Introduction to System Biology; Modeling in System Biology; Microarrays and Transcript Profiling; Biostatistics and Analysis of Large-Scale Biological Data; Proteomics; and Pharmacogenomics. These modules are taught by experts from different institutions belonging to GPBA. All modules of the short laboratory courses program are hands-on, namely these courses have extensive wet laboratory and/or e-laboratory sessions. Taken together with other GPBA activities such as research internships and continuous learning via GPBA Virtual Institute, the short course program will lead to the emergence of skilled researchers with sufficient understanding of new disciplines in high throughput biology. The initial development efforts for this project have been funded by the National Science Foundation Program Innovation Grant entitled Greater Philadelphia Bioinformatics Alliance and by BioAdvance, Biotechnology Greenhouse of Southeastern Pennsylvania. The proposed program is necessitated by the fact that thousands of graduate science and engineering students in America have no access to high throughput biology laboratories. The GPBA Project will have a positive impact on public health by training young scientists in both life sciences and computational sciences and enable them harvest and fuse methods from these disciplines for advancing the diagnosis and treatment of complex diseases.

描述（由申请人提供）： GPBA 高通量生物学短期实验室课程这一拟议项目的总体目的是培养一支能够跨越生物学、纳米技术和计算机科学学科界限的跨学科劳动力队伍。这样的劳动力将进一步发展生物信息学等最近新兴的领域，并帮助创建涉及高通量生物医学计算的新的跨学科。用于此目的的工具是大费城生物信息学联盟 (GPBA)，这是一个由区域研究和学术组织组成的联盟，致力于推进生物信息学和计算生物学——生物学和先进计算科学的整合正在彻底改变生命科学研究并保持显着改善医疗保健的承诺。通过将费城地区学术界、研究机构和私营部门的生物信息学人才的广泛知识库联系起来，GPBA 致力于为重大医疗、生命科学和环境挑战提供新的解决方案。该拨款请求支持为期八到十周的高通量生物学连续短期实验室课程。该序列由以下模块组成：系统生物学简介；系统生物学建模；微阵列和转录物分析；大规模生物数据的生物统计学和分析；蛋白质组学；和药物基因组学。这些模块由来自 GPBA 不同机构的专家教授。短期实验室课程的所有模块都是实践性的，即这些课程具有广泛的湿实验室和/或电子实验室课程。与其他 GPBA 活动（例如研究实习和通过 GPBA 虚拟学院的持续学习）相结合，短期课程计划将导致对高通量生物学新学科有充分了解的熟练研究人员的出现。该项目的初步开发工作得到了名为“大费城生物信息学联盟”的国家科学基金会计划创新拨款和宾夕法尼亚州东南部生物技术温室 BioAdvance 的资助。 由于美国数以千计的理工科研究生无法进入高通量生物实验室，因此拟议的计划是必要的。 GPBA 项目将通过培训生命科学和计算科学领域的年轻科学家，使他们能够收获和融合这些学科的方法来推进复杂疾病的诊断和治疗，从而对公共卫生产生积极影响。