Developing of a computer-based multimodal mind and body approach for mild cognitive decline

开发基于计算机的多模式身心方法来治疗轻度认知衰退

• 批准号: 10699442
• 负责人: JIAN KONG
• 金额: $ 49.81万
• 依托单位: BRAIN THRIVE TECHNOLOGY LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10699442
• 关键词: Acupressure; Acupuncture Therapy; Adherence; Adult; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease therapy; Antiinflammatory Effect; Area; Baduanjin; Benchmarking; Breathing; Characteristics; Clinic; Clinical Research; Cognition; Cognitive; Computers; Connective Tissue; Dementia; Development; Disease; Elderly; Exercise; Feasibility Studies; Goals; Guided imagery; Hippocampus; Home; Hospitals; Impaired cognition; Individual; Instruction; Intervention; Medial; Medicine; Memory; Memory Loss; Methods; Movement; Muscle relaxation phase; Neurologic; Participant; Patients; Performance; Persons; Pharmacological Treatment; Phase; Posture; Prefrontal Cortex; Prevention; Preventive therapy; Privatization; Probability; Psyche structure; Qi; Randomized; Regulation; Relaxation Techniques; Research; Rest; Safety; Small Business Technology Transfer Research; System; Tendon structure; Testing; Time; Ventral Tegmental Area; Video Recording; Work; age related; clinical diagnosis; clinical efficacy; cognitive function; cognitive training; cost effective; design; effective therapy; gray matter; improved; innovation; locus ceruleus structure; mild cognitive impairment; mind/body; multimodality; normal aging; novel; preference; primary outcome; programs; prototype; recruit; response; satisfaction; strength training; theories; treatment effect; web site

Summary Mild cognitive impairment (MCI) represents an intermediate state between normal aging and the diagnosis of clinically probable very early Alzheimer's disease (AD). Since MCI manifests before the onset of AD, it may be the optimal stage in which to intervene with preventative therapies for AD and age-related dementia before progressive neurological loss and irreversible cognitive impairment. Nevertheless, pharmacologic treatment for MCI is far from satisfactory, highlighting the urgent need for new treatment solutions for MCI. Baduanjin (BDJ) is a unique and innovative mind-body exercise characterized by the interplay of symmetrical physical postures and movements, focusing on strengthening muscles and tendons. It consists of eight simple movements that can be easily practiced at home when guided by videos /audio. These characteristics make it a suitable option for older adults with MCI. Studies from both our group and others have demonstrated its potentials for improving cognitive function for older adults with MCI. Nevertheless, studies also showed that the response to BDJ varies significantly, some individuals demonstrate only a moderate response. To overcome the challenge, this application aims to integrate BDJ with other mind and body approaches to develop a more effective treatment option for MCI. The goal of this Phase I R41 (STTR) application is to develop a computer-based multimodal mind and body approach (cbMMBA) to improve the cognitive function for MCI. Specifically, we will first develop a functional cbMMBA platform (prototype) integrating BDJ, acupressure, and relaxation techniques (Aim 1). We chose these methods, not only because some of these methods alone have demonstrated their potential to improve cognitive function in MCI / dementia, but because they also can interact with each other positively to produce synergistic effects. Next, we will perform a feasibility study using the cbMMBA on MCI (Aim 2). This application, if successful, will provide a cost-effective and easily accessible treatment option for MCI and other age-related dementia, significantly improve the prevention of MCI development, and directly benefit patients suffering from the highly prevalent disorder, particularly for those who may have limited access to in- person mind and body interventions.

概括 轻度认知障碍（MCI）代表正常衰老与诊断之间的中间状态 临床上可能很早的阿尔茨海默氏病（AD）。由于MCI在AD发作之前表现出来，可能是 干预预防性疗法的AD和年龄相关痴呆的最佳阶段 进行性神经系统丧失和不可逆转的认知障碍。然而，用于药理学治疗 MCI远非令人满意，强调了对MCI的新治疗解决方案的迫切需求。 Baduanjin（BDJ）是一种独特而创新的思维练习，其特征是对称的相互作用 身体姿势和运动，专注于增强肌肉和肌腱。它由八个简单组成 在视频 /音频指导的指导下，可以在家中轻松练习的动作。这些特征使得 对于患有MCI的老年人的合适选择。我们小组和其他人的研究都证明了它的 改善MCI老年人认知功能的潜力。然而，研究还表明 对BDJ的反应差异很大，有些人仅表现出适度的反应。克服 面临的挑战，该应用程序旨在将BDJ与其他思想和身体方法相结合，以开发更多 MCI的有效治疗选择。 该阶段I R41（STTR）应用程序的目标是开发基于计算机的多模式和身体 方法（CBMMBA）以改善MCI的认知功能。具体来说，我们将首先发展一个功能 CBMMBA平台（原型）集成了BDJ，穴位压力和放松技术（AIM 1）。我们选择了 这些方法，不仅是因为仅这些方法就证明了它们有可能改善的潜力 MCI /痴呆症中的认知功能，但因为它们也可以互相互动以产生 协同作用。接下来，我们将使用MCI上的CBMMBA进行可行性研究（AIM 2）。 如果成功的话，该应用程序将为MCI和 其他与年龄相关的痴呆症，显着改善了MCI发展的预防，并直接受益 患有高度普遍疾病的患者，特别是对于那些可能有限的IN-患者 人的思想和身体干预。