Mechanistic Studies on video guided acupuncture imagery treatment of pain

视频引导针灸意象治疗疼痛的机理研究

• 批准号: 9206721
• 负责人: JIAN KONG
• 金额: $ 42.58万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2018-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9206721
• 关键词: Absence of pain sensation; Acupuncture Points; Acupuncture Therapy; Affect; Affective; Aftercare; Analgesics; Anterior; Behavioral; Biological Neural Networks; Brain; Brain imaging; Brain region; Caring; Clinical; Clinical Treatment; Complement; Crossover Design; Degenerative polyarthritis; Development; Devices; Disabled Persons; Disease; Dorsal; Elderly; Electroacupuncture; Empathy; Event; Feeling; Foundations; Functional Magnetic Resonance Imaging; Gossypium; Healed; Health; Home environment; Human; Image; Imagery; Imagination; Individual; Insula of Reil; Investigation; Knee Osteoarthritis; Literature; Manuals; Medical; Meta-Analysis; Methods; Mind-Body Intervention; Mining; Modality; Nature; Needles; Neurocognitive; New York; Outcome; Pain; Pain Threshold; Pain intensity; Pain management; Participant; Patients; Pattern; Perception; Phase; Pilot Projects; Placebos; Process; Psyche structure; Publishing; Randomized; Recruitment Activity; Regulation; Research; Rest; Role; Science; Self-Administered; Sensory; Signal Transduction; Social Psychology; Somatosensory Cortex; Stimulus; Support System; Swab; System; Testing; Therapeutic; Therapeutic Effect; Touch sensation; Uncertainty; Visual; abstracting; base; brain pathway; chronic pain; cingulate cortex; comparative; experience; functional improvement; healing; improved; knee pain; mental imagery; midbrain central gray substance; mind body interaction; neuroimaging; neuromechanism; novel; operation; patient population; relating to nervous system; response; systematic review; treatment group; trend

Project Summary / Abstract The use of imagery to treat illness is one of the oldest medical practices. Nevertheless, the mechanism of the treatment remains unknown. Recent brain imaging studies suggest that underlying the functional nature of mental imagery may be the overlapping neurocognitive operations that support imagination, perception, and action. Acupuncture is an ancient invasive therapeutic method. Previous studies have shown that both the experience of acupuncture needle stimulation and the visualization of acupuncture needle stimulation can provoke overlapping brain activation, which suggests that visualizing or imagining acupuncture may achieve therapeutic effects through a brain pathway similar to actual acupuncture treatment. This application will investigate the underlying brain mechanisms of video-guided acupuncture imagery treatment (VGAIT), a novel mind-body treatment modality. In this treatment, subjects will watch a video of acupuncture previously administered on their own bodies and imagine this prior treatment being concurrently applied. In the R61 phase, using a crossover design and functional magnetic resonance imaging (fMRI), we will investigate the cortical fMRI signal changes and resting state functional connectivity changes evoked by 1) VGAIT, 2) VGAIT control condition (subjects will watch a video of a cotton swab touching specific points on their bodies and imagine it being concurrently applied), 3) verum acupuncture, and 4) sham acupuncture administered on healthy subjects. In the R33 phase, knee osteoarthritis (OA) patients will be recruited and randomized to one of four treatment groups for one month: 1) VGAIT, 2) a VGAIT control condition, 3) verum acupuncture, and 4) sham acupuncture. We will investigate the fMRI signal changes and resting state functional connectivity changes evoked by the different conditions. This project will facilitate the development of new mind-body intervention methods that can directly benefit patients suffering from chronic pain. It would be especially beneficial to elderly and disabled patients who have limited access to acupuncture and medical care and could benefit from self- administered, at-home treatment following acupuncture treatment sessions. Most importantly, a comparative investigation of imagery acupuncture, real acupuncture, and sham acupuncture will deepen our understanding of mind-body interaction, imagery treatment, acupuncture, and pain management.

项目摘要 /摘要 使用图像治疗疾病是最古老的医学习惯之一。然而， 治疗机制仍然未知。最近的大脑成像研究表明基础 心理图像的功能性质可能是重叠的神经认知操作 支持想象，感知和行动。针灸是一种古老的侵入性治疗方法。 先前的研究表明，针灸刺激的经验和 针灸刺激的可视化会引起重叠的大脑激活，这会引起重叠的激活 建议可视化或想象针灸可以通过大脑实现治疗作用 类似于实际针灸治疗的途径。 该应用将研究视频引导针灸的潜在大脑机制 图像处理（VGAIT），一种新颖的身心处理方式。在这种治疗中，受试者将 观看以前在自己的身体上管理的针灸视频，并想象一下此事 处理同时应用。在R61阶段，使用跨界设计和功能 磁共振成像（fMRI），我们将研究皮质fMRI信号变化和静止 状态功能连接性变化由1）VGAIT诱发，2）VGAIT控制条件（受试者将 观看棉签上触摸身体上特定点的视频，并想象它是 同时使用），3）verum针灸，4）在健康上给药的假针刺 主题。在R33阶段，膝盖骨关节炎（OA）患者将被招募并随机分为一个 在一个月的四个治疗组中：1）vgait，2）vgait控制条件，3）verum 针灸和4）假针刺。我们将研究fMRI信号变化和静止状态 功能连通性变化由不同条件引起。 该项目将有助于开发新的思维体干预方法，这些方法可以直接 有益于患有慢性疼痛的患者。这对老年人和残疾人特别有益 获得针灸和医疗服务的患者，可以从自我 针灸治疗课程后，进行了家庭治疗。最重要的是， 图像针灸，实际针灸和假针刺的比较研究将 加深我们对心身互动，图像处理，针灸和痛苦的理解 管理。