Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in

使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型，以分析白细胞介素 17 抑制剂的细胞和表观遗传效应

• 批准号: 2890513
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2027
• 资助国家: 英国
• 起止时间: 2027 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2890513
• 关键词: Developing; 3D; printed; skin; model

There are now a wealth of treatments for psoriasis (Ps), a chronic non contagious autoimmune skin disease usually arising in inflamed red and white scaly patches of skin. Ps has no known cure but symptoms can be controlled by treatments such as steroid creams and UV light. Ps affects 2-3 % of the population and 125million people worldwide. Although biological therapeutics have revolutionised the treatment of disease, there is still a significant proportion of patients that fail to respond, patients that relapse and long term, drug free remission is not readily achievable. There is evidence how skin from Ps patients is differentially methylated compared to that of healthy skin, with the implication that this methylation may maintain keratinocytes in a hyper-inflammatory state. Long term treatment response may therefore be dependent on the control of this methylation state.

银屑病 (Ps) 是一种慢性非传染性自身免疫性皮肤病，通常出现在发炎的红色和白色鳞状皮肤斑块中，现在有多种治疗方法。 Ps 尚无已知的治疗方法，但可以通过类固醇霜和紫外线等治疗来控制症状。 Ps 影响着全球 2-3% 的人口和 1.25 亿人。尽管生物疗法已经彻底改变了疾病的治疗方法，但仍有相当一部分患者无法做出反应，患者会复发，并且长期、无药物缓解是不容易实现的。有证据表明，与健康皮肤相比，PS 患者的皮肤存在差异性甲基化，这表明这种甲基化可能使角质形成细胞维持在高炎症状态。因此，长期治疗反应可能取决于对这种甲基化状态的控制。