Neural Bases of Effectiveness of Individually-Tailored Smoking Cessation Messages

个性化戒烟信息有效性的神经基础

基本信息

批准号：
7385559
负责人：
VICTOR J STRECHER
金额：
$ 38万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-20 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7385559
关键词：
Abstinence Address Alcohol or Other Drugs use Amygdaloid structure Anterior Area Biological Markers Brain Brain region Cigarette Smoker Class Cognitive Communication Methods Communication Research Community Health Computers Condition Dimensions Effectiveness Emotional Exposure to Feedback Functional Magnetic Resonance Imaging Generations Grant Health Communication Image Imaging Techniques Instruction Intention Interactive Communication Internet Intervention Knowledge Lead Magnetic Resonance Imaging Medial Meta-Analysis Michigan Motor Neurosciences Research Nicotine Dependence Nucleus Accumbens Numbers Online Systems Outcome Participant Pathway interactions Pattern Phase Phase II Clinical Trials Prefrontal Cortex Preparation Procedures Process Psychology Public Health Rate Relative (related person)Research Research Methodology Research Personnel Role Schools Self-control as a personality trait Series Smoke Smoker Smoking Smoking Cessation Intervention Standards of Weights and Measures Stimulus Technology Testing Time Tobacco Universities Variant Work base cognitive neuroscience cost design follow-up health care service organization improved innovation insight interest programs relating to nervous system response reward processing self help smoking cessation tailored messaging tool

项目摘要

DESCRIPTION (provided by applicant): While tailored smoking cessation interventions have generally demonstrated positive outcomes, the mechanisms by which people respond to these interventions are less well understood. We are proposing a series of studies that examines the neural substrates associated with smoking cessation messages individually tailored to smokers' needs and interests. The proposed project uniquely combines cognitive neuroscience and public health communications methods to investigate how smokers respond to tailored smoking cessation messages. We have demonstrated in a preliminary functional magnetic resonance imaging (fMRI) study that smokers receiving high-tailored smoking cessation messages (compared to low-tailored cessation messages) showed greater medial prefrontal cortex (MPFC) activation, consistent with the role of MPFC in processing self-relevant material. To further investigate the neural substrates that respond to specific tailored smoking cessation messages and importantly the relationship of these findings to subsequent actual smoking cessation, we propose two studies, each with two phases. Study 1a (Phase I) investigates the role of self-relevance in targeted messaging for smoking cessation. We will examine the relative activation of the MPFC in each subject during exposure to highly self-relevant, high-tailored smoking cessation messages in contrast to low-tailored self-relevant messages and a control self-relevance task. 88 cigarette smokers will receive high-tailored and low-tailored self-relevant smoking cessation messages during fMRI, and will also complete a control task testing self-relevance (Phan et al., 2004). The findings will inform whether greater MPFC activation to high- tailored self-relevant smoking cessation messages is associated with greater self-referential processing. In Study 1b (Phase 2), we will administer to each Study 1a participant a previously tested web-based tailored smoking cessation program immediately following the fMRI scanning (Study 1a) session. Subjects will be followed up in four months and assessed on actual smoking abstinence. Study 1b will explore associations between specific brain region activations from self-relevant smoking messages and subsequent cessation. Study 2 investigates the role of two different types of smoking cessation messages: motivational messages (why to quit) and instructional messages (how to quit) in targeted messaging for smoking cessation. In Study 2a (Phase1), another 88 cigarette smokers will receive high-tailored motivational messages, high-tailored instructional messages, and neutral messages during fMRI. In Study 2b (Phase 2), Study 2a participants will receive the web-based tailored smoking cessation program immediately after the fMRI scanning session and then be followed up in four months to determine actual smoking abstinence. Study 2b will explore the relationship between specific brain region activations in response to tailored motivational and instructional cessation messages and subsequent cessation. The results of these studies will begin to identify specific pathways for optimal message tailoring to make the largest impact on smoking cessation. Nicotine addiction is an important public health concern. The project combines public health, psychology, and neuroscience research methods to understand how smokers respond to individualized smoking cessation messages in an effort to improve smoking cessation programs.

描述（由申请人提供）：虽然量身定制的戒烟干预措施通常表现出积极的结果，但人们对这些干预措施做出反应的机制知之甚少。我们提出了一系列研究，该研究研究了与吸烟者的需求和兴趣分别量身定制的与戒烟消息相关的神经底物。拟议的项目独特地结合了认知神经科学和公共卫生传播方法，以调查吸烟者如何应对量身定制的戒烟信息。我们已经在初步功能磁共振成像（fMRI）研究中证明了接受高量吸烟戒烟消息的吸烟者（与低固定的戒烟消息相比）显示出更大的内侧前额叶皮层（MPFC）激活，这与MPFC在处理自含量材料中的作用一致。为了进一步研究对特定量身定制的戒烟信息做出反应的神经底物，重要的是，这些发现与随后的实际吸烟戒烟的关系，我们提出了两项研究，每个研究都有两个阶段。研究1A（I阶段）研究了自相关性在暂停暂停的靶向消息中的作用。我们将在暴露于高度自我相关的戒烟消息中，在暴露于高量的自我相关消息和控制自我咨询任务的情况下，我们将检查每个受试者中MPFC的相对激活。 88个吸烟者将在功能磁共振成像期间获得高量和低量的自我相关的吸烟消息，还将完成控制任务测试自相关性（Phan等，2004）。这些发现将告知更大的MPFC激活对高量量的自我相关的戒烟信息是否与更大的自指加工有关。在研究1B（第2阶段）中，我们将对每位研究1A参与者进行一次先前测试的基于Web的量身定制的戒烟计划（研究1A）会议。受试者将在四个月内进行跟踪，并根据实际的戒烟进行评估。研究1B将探索自我相关的吸烟信息和随后停止的特定大脑区域激活之间的关联。研究2调查了两种不同类型的戒烟消息的作用：动机信息（为什么退出）和教学信息（如何退出）在有针对性的消息传递中进行戒烟。在研究2a（阶段1）中，另外88名吸烟者将收到高量的动机信息，高量子的教学消息和fIMRI期间中立消息。在研究2B（第2阶段）中，研究2A参与者将在功能磁共振成像扫描会议后立即获得基于网络的量身定制的戒烟计划，然后在四个月内进行跟进以确定实际的戒烟。研究2b将探讨特定的大脑区域激活之间的关系，以响应量身定制的动机和教学戒烟信息以及随后的停止。这些研究的结果将开始确定特定的途径，以使最佳消息量身定制，以对戒烟产生最大的影响。尼古丁成瘾是重要的公共卫生问题。该项目结合了公共卫生，心理学和神经科学研究方法，以了解吸烟者如何应对个性化的戒烟信息，以改善戒烟计划。