A Biliary Tract-Specific Fluorescence Image-guided Surgery

胆道特异性荧光图像引导手术

• 批准号: 10323760
• 负责人: Richard Jaepyeong Cha
• 金额: $ 25.66万
• 依托单位: OPTOSURGICAL, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2023-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10323760
• 关键词: Adoption; Anatomy; Animals; Bile duct carcinoma; Bile fluid; Biliary; Blood Vessels; Cessation of life; Child; Cholecystectomy; Clinical; Color Visions; Common bile duct structure; Complex; Custom; Cystic duct structure; Development; Devices; Dissection; Duct (organ) structure; Dyes; Endoscopy; Engineering; Environment; Excision; Extrahepatic; Eye; Family suidae; Fluorescence; Fluorescent Dyes; Fostering; Future; Goals; Hand; Hemorrhage; Hepatectomy; Hepatic; Hepatobiliary; Hospitals; Human; Image; Image-Guided Surgery; Imaging Techniques; Imaging technology; Impairment; Incidence; Individual; Indocyanine Green; Intelligence; Intrahepatic bile duct; Label; Laparoscopes; Laparoscopic Cholecystectomy; Laparoscopy; Laser Speckle Imaging; Lead; Length of Stay; Liver; Liver neoplasms; Liver parenchyma; Malignant neoplasm of liver; Modeling; Morbidity - disease rate; Multi-modal optical imaging; Operative Surgical Procedures; Optics; Outcome; Palpation; Pathway interactions; Pediatric Research; Perfusion; Phase; Physiological; Physiology; Positioning Attribute; Primary Malignant Neoplasm of Liver; Recovery; Research; Shapes; Short Waves; Site; Source; Structure; Surface; Surgeon; Surgical complication; System; Technical Expertise; Techniques; Technology; Testing; Time; Tissues; Touch sensation; Ultrasonography; Validation; Vision; Visual; Visualization; Work; bile duct; biliary tract; burden of illness; clinical translation; fluorescence imaging; image guided; imager; imaging platform; imaging system; improved; improved functioning; improved outcome; intrahepatic; minimally invasive; mortality; multimodality; next generation; novel; optical imaging; porcine model; pre-clinical; preclinical study; research and development; robot assistance; sensor; sensor technology; surgery outcome; tool

Abstract The primary liver cancer including intrahepatic bile duct cancer pose significant global burden of illness with increasing incidence and mortality in US and around the world. Surgery remains the most effective form of treatment. However, surgical complication rates for medium to high complexity hepatectomies persist in 30-40% range even in highly skilled hands and at high volume centers. The critical challenges appear to be attributable to navigating liver parenchymal dissection, where size of resection surface, associated with blood loss and missed bile leaks from the liver parenchyma, and prolonged operative time during dissection pose significant obstacle. In this research, we propose to develop an upgraded laparoscopic imager for deeper biliary-specific fluorescent imaging using a short-wave infrared (SWIR) sensor and high-definition RGB color vision, and to test the utility of our multimodal laparoscopic imaging technique in liver surgery throughout preclinical swine studies. The clear anatomic display of intrahepatic critical structures and functional physiology will make the hepatic dissection safer and more efficient for any liver resection. The goal of this 1-year research is to develop and evaluate the novel biliary-specific fluorescence and laparoscopic vision/display through the following specific aims; Aim1: To develop a formfactor SWIR camera system for fluorescence image-guided laparoscopy; Aim 2: To validate the usefulness of the developed new vision platform in preclinical animal studies.

抽象的 包括肝内胆管癌在内的原发性肝癌造成了巨大的全球疾病负担 美国和世界各地的发病率和死亡率不断增加。手术仍然是最有效的 治疗形式。然而，中度至高度复杂性肝切除术的手术并发症发生率 即使在高技术人员和高产量中心，该比例也能维持在 30-40% 的范围内。严峻的挑战 似乎归因于导航肝实质解剖，其中切除表面的大小， 与肝实质失血和漏胆漏以及手术时间延长有关 解剖过程中的时间构成了重大障碍。 在这项研究中，我们建议开发一种升级的腹腔镜成像仪，用于更深入的胆道特异性 使用短波红外 (SWIR) 传感器和高清 RGB 彩色视觉的荧光成像， 并测试我们的多模态腹腔镜成像技术在肝脏手术中的实用性 临床前猪研究。肝内关键结构和功能的清晰解剖显示 生理学将使肝解剖对于任何肝脏切除术来说都更安全、更有效。目标是 这项为期一年的研究旨在开发和评估新型胆道特异性荧光和腹腔镜检查 通过以下具体目标进行愿景/展示；目标1：开发外形短波红外相机 荧光图像引导腹腔镜检查系统；目标 2：验证该方法的实用性 在临床前动物研究中开发了新的视觉平台。

项目成果

Assessment of a novel biliary-specific near-infrared fluorescent dye (BL-760) for intraoperative detection of bile ducts and biliary leaks during hepatectomy in a preclinical swine model.

评估一种新型胆道特异性近红外荧光染料 (BL-760)，用于临床前猪模型肝切除术中胆管和胆漏的术中检测。

• 发表时间: 2023-07
• 影响因子: 2.4
• 作者: Saruwatari, Michele S;Jawed, Kochai;Ali, Khalid M;Ning, Bo;Naik, Sailee;Nam, So;Schnermann, Martin J;Sandler, Anthony;Cha, Richard J
• 通讯作者: Cha, Richard J

A coaxial excitation, dual-red-green-blue/near-infrared paired imaging system toward computer-aided detection of parathyroid glands in situ and ex vivo.

一种同轴激发、双红-绿-蓝/近红外配对成像系统，用于计算机辅助检测甲状旁腺原位和离体。

• 发表时间: 2022-08
• 作者: Kim, Yoseph;Lee, Hun Chan;Kim, Jongchan;Oh, Eugene;Yoo, Jennifer;Ning, Bo;Lee, Seung Yup;Ali, Khalid Mohamed;Tufano, Ralph P;Russell, Jonathon O;Cha, Jaepyeong
• 通讯作者: Cha, Jaepyeong