Superior Medical Scintillators by Vapor Deposition

采用气相沉积技术的高级医用闪烁体

基本信息

批准号：
7230237
负责人：
VINOD K SARIN
金额：
$ 19.71万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-01 至 2010-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7230237
关键词：
Achievement Address Applied Research Area Basic Science Boston Breeding Budgets Caliber Ceramics Chemicals Clinical Communities Condition Country Dental Dental Radiology Deposition Development Devices Diagnostic Diagnostic radiologic examination Digital Mammography Dimensions Elements Equipment Evaluation Film Goals Growth Housing Human Resources Image Image Enhancement Individual Kinetics Laboratories Lasers Legal patent Light Lutetium Mammography Medical Morphology Motivation Noise Numbers Optics Output Oxides Performance Principal Investigator Process Production Property Purpose Radiation Monitoring Radiology Specialty Range Refractive Indices Refractory Research Resolution Resources Role Sarin Shapes Specimen Spectrum Analysis Standards of Weights and Measures Structure System Systems Analysis Techniques Technology Testing Theoretical Studies Thermodynamics Thick Time Transcend Universities Work aluminosilicate base commercial application commercialization cost data management density detector digital digital imaging innovation member monitoring device multidisciplinary new technology novel strategies physical property practical application programs prototype quantum radiologist size skills success vapor

项目摘要

DESCRIPTION (provided by applicant): Limitations in detector performance have kept medical radiology from utilizing and enjoying the full benefits of digital technology. The major obstacles have been material performance and lack of viable commercial processes to fabricate large area screens. We propose to develop a new technology for the synthesis of such scintillating screens based on vapor deposition of films, a technology ideally suited to this purpose. Initially we intend to work with a new scintillator material, a Lu2O3 optical ceramic, which has displayed impressive performance in dental x-ray applications. However its utilization and commercialization for medical applications has been impractical because of the way materials and devices are currently fabricated. The two processes that are directly responsible, namely hot pressing (which limits size and shape) and laser pixelation (time-consuming and expensive), will be eliminated by the new technology we propose, resulting in a new breed of .advanced scintillators. We . will begin by utilizing PVD to fabricate exploratory coatings that wilLenable early characterization and evaluation. This will provide valuable information for our primary effort on CVD, which is our process of choice for achieving the thicknesses that will ultimately be heeded. Guided by chemical thermodynamics and kinetics, we will deposit fully dense transparent films of this material in thicknesses >200 jam, and areas up to10 cm2 (limited only by our experimental equipment size). We will further seek to control the microstructure, and use tailored substrates (using photoresist techniques) so as to enhance channeling of the emitted light toward the photodetectorand to minimize laterial scattering. The success of this research will advance the performance of systems for digital radiology beyond that of conventional film-screen technology and make possible the widespread replacement of the latter for general radiological applications. This will for the first time make the benefits of digital techniques in data management, image enhancement, and differential analysis widely available to the broad medical radiological community.

描述（由申请人提供）：检测器性能的限制使医学放射学无法利用和享受数字技术的全部好处。主要的障碍是物质性能和缺乏可行的商业过程来制造大面积屏幕。我们建议开发一种新技术，以基于胶片的蒸气沉积来综合这种闪烁的屏幕，这是一项非常适合此目的的技术。最初，我们打算使用一种新的闪光灯材料（一种LU2O3光学陶瓷），在牙科X射线应用中表现出令人印象深刻的性能。但是，由于目前材料和设备的制造方式，其用于医疗应用的利用和商业化是不切实际的。直接负责的两个过程，即热压（限制尺寸和形状）和激光像素化（耗时且昂贵），我们将被我们提出的新技术消除，从而导致新型的.Advanced闪烁体。我们。将首先利用PVD来制造探索性涂层，以期早期表征和评估。这将为我们在CVD上的主要努力提供宝贵的信息，这是我们选择最终会注意的厚度的选择。在化学热力学和动力学的指导下，我们将以厚度> 200堵塞的完全致密的透明膜沉积，最高为10 cm2（仅受我们的实验设备尺寸限制）。我们将进一步寻求控制微观结构，并使用量身定制的底物（使用光片技术），以增强发射光向光电轨道和光电轨道的通道，以最大程度地减少侧向散射。这项研究的成功将使数字放射系统系统的性能超越传统的胶片屏幕技术，并使后者的广泛替换成为一般放射学应用程序。这将首次在数据管理，图像增强和差异分析中获得数字技术的好处，并广泛可用于广泛的医学放射学界。