Training in Developmental Hematology

发育血液学培训

• 批准号: 7168330
• 负责人: KATHLEEN M. SAKAMOTO
• 金额: $ 26.25万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7168330
• 关键词: Development; Hematology; Training

DESCRIPTION (provided by applicant): Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Very little is understood about the molecular pathogenesis of most of the hematologic diseases in children. At UCLA, we have a tremendous resource of interdisciplinary investigators whose research focuses on a wide spectrum of topics related to developmental hematology. Therefore, we propose a unique training program that focuses specifically on pediatric hematologic diseases by integrating a variety of disciplines, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, hemostasis and thrombosis, transfusion medicine, novel technologies (RNA interference, proteomics, genomics), hematologic malignancies, therapeutics, and mathematical modeling. Given the declining number of physician-scientists in Pediatric Hematology, a training program in Developmental Hematology would be critical to advance the field. In this application, we seek funding for 4 postdoctoral fellows per year for 5 years. The fellows will be either MDs, MD/PhDs, or PhDs. Trainees will have the opportunity to develop research in one of the 22 faculty member's laboratories. Trainees will be selected from a large pool of postdoctoral fellows (approximately 80 per year) based on their academic and research achievements. Appointments will be for two years, the second year appointment being dependent on a progress report. Trainees will participate in journal clubs, lectures related to pediatric hematology, and seminars. They will also take a required course on Developmental Hematology through the Department of Pathology. All trainees will be expected to meet with a Scholarship Oversight Committee every 6 months to monitor progress and productivity. They will present their work at national meetings. Many investigators have pre-existing collaborations and publications. We hope to utilize the strengths of UCLA, including the breadth and depth of investigators across many disciplines, to train future researchers and leaders in the field of Pediatric Hematology. (End of Abstract)

描述（由申请人提供）： 小儿血液疾病的研究为理解调节造血的基本机制提供了重要的范例。与成人血液学疾病不同，许多儿科疾病是由控制血细胞发育或功能的内在遗传缺陷引起的。关于儿童大多数血液学疾病的分子发病机理的理解很少。在加州大学洛杉矶分校（UCLA），我们拥有大量的跨学科研究人员资源，其研究重点是与发育血液学有关的广泛主题。因此，我们提出了一项独特的培训计划，该计划专门针对小儿血液学疾病，通过整合各种学科，包括分子和细胞造血，替代有机体模型，干细胞移植，止血和血栓形成，血管症和血栓形成，血管血管病，拥抱医学，新技术，蛋白质干扰，蛋白质组学，基因组学，疗程，疗程，疗程，疗程。鉴于儿科血液学中医师科学家的数量减少，发育血液学的培训计划对于推进该领域至关重要。 在此申请中，我们每年为5年的每年4个博士后研究员寻求资金。研究员将是MDS，MD/PHD或PHD。学员将有机会在22位教职员工之一的研究中进行研究。根据学术和研究成就，将从大量的博士后研究员（每年约80个）中选出学员。任命将为两年，第二年的约会取决于进度报告。学员将参加期刊俱乐部，与儿科血液学有关的讲座和研讨会。他们还将通过病理学系学习有关发育血液学的必要课程。预计所有学员将每6个月与一个奖学金监督委员会会面，以监控进步和生产力。他们将在国家会议上展示他们的作品。许多调查人员都有先前存在的合作和出版物。我们希望利用加州大学洛杉矶分校的优势，包括许多学科的调查人员的广度和深度来培训儿科血液学领域的未来研究人员和领导者。 （抽象的结尾）