Training in Pediatric Nonmalignant Hematology and Stem Cell Biology

儿科非恶性血液学和干细胞生物学培训

• 批准号: 8667356
• 负责人: KATHLEEN M. SAKAMOTO
• 金额: $ 15.72万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8667356
• 关键词: Childhood; Hematology; Non-Malignant; Training; stem cell biology

DESCRIPTION (provided by applicant): Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis and stem cell biology. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Very little is understod about the molecular pathogenesis of many of the hematologic diseases in children. We plan to develop an innovative, multidisciplinary training program in pediatric nonmalignant hematology and stem cell biology with investigators who have unique expertise and can foster "team science." Therefore, we propose a training program that integrates a variety of disciplines and expertise, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, novel technologies in proteomics/genomics, and bioinformatics. Currently, there is no program at Stanford University that supports the training of MD, MD/PhD, or PhD fellows to study Pediatric Nonmalignant Hematology and Stem Cell Biology. Given the declining number of translational and basic researchers in this area, a training program in nonmalignant hematology and stem cell biology will be critical to advance the field. In this application, we seek funding for two MD, MD/PhD, or PhD postdoctoral fellows per year for two years. Trainees will have the opportunity to develop research in one of the 23-faculty member's laboratories. Co-mentors and team science will be highly encouraged. Trainees will be selected from a pool of approximately 80 internal postdoctoral fellow candidates in addition to external candidates based on their academic potential, career goals, and research achievements. The second year of funding will depend on progress. Trainees will be required to participate in multidisciplinary journal clubs, hematology and stem cell biology lectures, clinic conferences, and joint research seminars. Trainees will also take a required course on Pediatric Nonmalignant Hematology and Stem Cell Biology (Pathology 290) with lectures given by the faculty mentors in the training program. Pediatric Hematology/Oncology MD or MD/PhD fellows will meet with their Scholarship Oversight Committees every 6 months to monitor progress and productivity. Trainees will present their work at national meetings, such as ASH, Keystone, and FASEB meetings. We hope to utilize the strengths of Stanford University to develop research collaborations in pediatric nonmalignant hematology and stem cell biology, including the breadth and depth of investigators across many disciplines, to train future leaders in the field.

描述（由申请人提供）：小儿血液疾病的研究为了解调节造血和干细胞生物学的基本机制提供了重要的范式。与成人血液学疾病不同，许多儿科疾病是由控制血细胞发育或功能的内在遗传缺陷引起的。 关于儿童许多血液学疾病的分子发病机理的理解很少。我们计划通过具有独特专业知识并且可以培养“团队科学”的研究人员，开发一项创新的，多学科的培训计划，并在儿科非恶性血液学和干细胞生物学方面开发。因此，我们提出了一个培训计划，该计划整合了各种学科和专业知识，包括分子和细胞造血，替代生物模型，干细胞移植，蛋白质组学/基因组学的新技术以及生物信息学的新技术。目前，斯坦福大学还没有支持MD，MD/PhD或博士学位研究员来研究小儿非恶性血液学和干细胞生物学的培训。鉴于该领域的转化和基础研究人员数量的减少，非恶性血液学和干细胞生物学方面的培训计划对于推进该领域至关重要。 在此应用程序中，我们每年为两年的两年中的两名MD，MD/PhD或博士后研究员寻求资金。学员将有机会在23名教职成员的实验室之一中开发研究。将鼓励联席和团队科学。除外部候选人外，还将根据他们的学术潜力，职业目标和研究成就，从大约80个内部博士后候选人中选出学员。资金的第二年将取决于进步。 学员将被要求参加多学科期刊俱乐部，血液学和干细胞生物学讲座，诊所会议和联合研究研讨会。学员还将在培训计划中的教师导师提供的讲座上，学习小儿非恶性血液学和干细胞生物学（病理290）的必要课程。小儿血液学/肿瘤学MD或MD/PhD研究员将每6个月与他们的奖学金监督委员会会面，以监控进度和生产力。学员将在全国会议上介绍他们的工作，例如Ash，Keystone和Faseb会议。我们希望利用斯坦福大学的优势开发小儿非恶性血液学和干细胞生物学方面的研究合作，包括许多学科的研究人员的广度和深度来培训该领域的未来领导者。