Prenatal Smoking, Fetal Behavior, and Infant Withdrawal

产前吸烟、胎儿行为和婴儿戒断症状

• 批准号: 7072327
• 负责人: LAURA R STROUD
• 金额: $ 41.7万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7072327
• 关键词: behavioral /social science research tag; child psychology; clinical research; developmental psychology; drug /alcohol abstinence; drug withdrawal; embryo /fetus; embryo /fetus monitoring; embryo /fetus pharmacology; embryo /fetus toxicology; human pregnant subject; human subject; longitudinal human study; maternal behavior; neuropsychological tests; neuropsychology; newborn human (0-6 weeks); nicotine; prenatal stress; psychopharmacology; smoking; stimulus /response; tobacco abuse; young adult human (21-34)

DESCRIPTION (provided by applicant): Maternal smoking during pregnancy has been linked to numerous adverse health outcomes in infancy and longer-term neurobehavioral outcomes. Relatively little attention, however, has focused on effects of prenatal smoking on offspring neurobehavior during the newborn and fetal periods. One key unanswered question is whether exposure to prenatal smoking induces neurobehavioral symptoms of withdrawal/abstinence in newborns. Short-term abstinence in adult regular smokers clearly results in symptoms of withdrawal. Furthermore, evidence from our group suggests alterations in neurobehavior consistent with signs of abstinence in smoking-exposed newborns, effects not evident at 10-30 days. However, although essential for resolving the question of withdrawal in infants, no studies have included intensive measurement of neurobehavior including signs of abstinence over the first month of life. Further, no previous studies of early neurobehavior in smoking-exposed infants have included physiological measures and measures of fetal neurobehavior. In the proposed study, we will conduct an intensive, short-term, longitudinal study of neurobehavior including signs of abstinence during the newborn and fetal periods in offspring continuously exposed and unexposed to prenatal smoking. Signs of abstinence will be assessed in the context of a comprehensive neurobehavioral examination and measures of newborn nicotine and cotinine levels. The proposed study includes one fetal neurobehavioral assessment during third trimester, followed by eight infant neurobehavioral assessments on days 0, 1,2, 3, 5, 7, 10, and 30 of life. Aims include a characterization of infant signs of abstinence and neurobehavior, dose response relations between prenatal smoking exposure and neurobehavior, physiological correlates of abstinence, and fetal signs of abstinence and neurobehavior. The proposed study will allow us to identify potential signs of abstinence in smoking exposed infants and fetuses and to differentiate immediate versus more persistent neurobehavioral deficits resulting from prenatal smoking exposure. Given that signs of abstinence may interfere with maternal-newborn relationships, results may lead to targeted intervention with newborns and education for parents to improve interactions with exposed newborns. The proposed study may also help to identify infants who may be at risk for the long-term consequences of prenatal smoking, and, potentially might, lead to novel intervention and prevention efforts for pregnant smokers.

描述（由申请人提供）：怀孕期间的孕产妇吸烟与婴儿期和长期神经行为结局的许多不良健康结果有关。然而，相对较少的关注集中在新生儿和胎儿时期对产前吸烟对后代神经行为的影响。一个关键的未解决的问题是，暴露于产前吸烟是否会引起新生儿戒断/戒酒的神经行为症状。成年常规吸烟者的短期禁欲显然会导致戒断症状。此外，我们小组的证据表明，神经行为的改变与暴露于吸烟的新生儿的戒酒迹象一致，在10-30天内效果不明显。但是，尽管对于解决婴儿戒断问题至关重要，但没有研究包括对神经行为的深入测量，包括在生命的第一个月中禁欲的迹象。此外，先前对暴露于吸烟的婴儿的早期神经行为的研究包括胎儿神经行为的生理措施和措施。 在拟议的研究中，我们将对神经行为的密集，短期，纵向研究，包括在新生儿和胎儿时期的禁欲迹象，后代不断暴露并暴露于产前吸烟。禁欲的迹象将在全面的神经行为检查和新生儿尼古丁和可替宁水平的措施的背景下进行评估。拟议的研究包括三个月期间的一项胎儿神经行为评估，然后在第0、1,2、3、5、7、10和30天进行八个婴儿神经行为评估。目的包括戒酒和神经行为的婴儿迹象的表征，产前吸烟与神经行为之间的剂量反应关系，禁欲的生理相关性以及戒酒和神经be虫的胎儿迹象。 拟议的研究将使我们能够确定吸烟暴露的婴儿和胎儿中禁欲的潜在迹象，并区分产前吸烟引起的立即与更持续的神经行为缺陷。鉴于禁欲的迹象可能会干扰孕产妇的关系，结果可能会导致针对新生儿的有针对性的干预，并为父母提供教育，以改善与裸露的新生儿的互动。拟议的研究还可能有助于确定可能有可能长期吸烟后果的婴儿，并且可能会导致对孕妇吸烟者的新干预和预防努力。