A High-Field (7T) MRI System for Translational Imaging Research

用于转化成像研究的高场 (7T) MRI 系统

• 批准号: 7125727
• 负责人: MICHAEL DUFF DAVIS
• 金额: $ 195万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125727
• 关键词: Aging; Angiography; Animal Experimentation; Animal Housing; Animal Model; Animals; Autopsy; Biochemical; Biomedical Research; Blood; Blood flow; Brain; Caliber; Cardiac; Chemical Shift Imaging; Choline; Clinical Trials; Communities; Complex; Data; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Discipline; Echo-Planar Imaging; Edema; Electric Stimulation; Environment; Equipment; Extravasation; Foundations; Frequencies; Functional Magnetic Resonance Imaging; Funding; Future; Gadolinium; Glutamates; Grant; Health Sciences; Human; Image; Injury; Inositol; Invasive; Life; Light; Localized; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetism; Maps; Marketing; Measurement; Measures; Mental disorders; Microscopy; Modality; Nerve; Nerve Degeneration; Neurologic; Neurons; Oxygen; Pathway interactions; Performance; Perfusion; Phospholipids; Physiologic pulse; Primates; Process; Pulse taking; Rate; Research; Research Personnel; Resolution; Rodent; Sampling; Scanning; Sensory; Signal Transduction; Site; Slice; Smell Perception; System; Tactile; Technology; Testing; Time; Tissues; Training; Transgenic Mice; United States National Institutes of Health; Veterans; Weight; blood oxygen level dependent; catalyst; design; gamma-Aminobutyric Acid; human disease; human tissue; improved; in vivo; innovation; instrument; interest; medical schools; nonhuman primate; oncology; pre-clinical; pre-clinical research; response; size; sound; tool; ultra high resolution; white matter

DESCRIPTION (provided by applicant): The objective of this proposal is to seek funding for the purchase of a small-bore, 7T MRI scanner to be installed at the UT Health Science Center at San Antonio (UTHSCSA). Commissioning of this instrument will help resolve a cross-institutional demand for a high-resolution animal MRI. It will serve the regional biomedical academic communities located at the UTHSCSA, the Southwest Foundation for Biomedical Research (SFBR), the Audie Murphy Memorial Veterans Hosp. and the UT San Antonio. An advanced Bruker ClinScan MR system has just emerged on the market and represents a much needed leading-edge technology employing a high-performance pulsed magnetic gradient field and 32-channel parallel RF systems. Driven by a Siemens Syngo consol with IDEAMRI pulse sequencing, this instrument will now enable users to perform such demanding studies as dynamic rodent fMRI and cardiac imaging. Scanning modalities yielding superior spatial and temporal resolution not previously achievable with our existing 2T and 3T human MRI's include anatomical MR microscopy (~100um resolution), BOLD (oxygen utilization), MR spectroscopy, contrast-perfusion MRI (blood flow) and diffusion tensor imaging (white matter connectivity). While this proposal will initially serve the more well-established NIH investigator, these powerful features will undoubtedly attract other investigators to acquire pilot data to fuel new NIH grant submissions. Because this MRI can accommodate a wide variety of animal sizes and species from transgenic mice to non-human primates, as well as necropsied human tissue, we expect to generate interest spanning multiple disciplines such as oncology, aging, neurological and psychiatric disorders. We anticipate that this new tool will act as a catalyst in spawning innovative strategies to solve complex hypotheses. The RIC is a department-level unit within the UTHSCSA School of Medicine whose charter is to develop non-invasive imaging for basic preclinical and clinical investigation. It has outstanding facilities dedicated exclusively for research. This includes a recent expansion of its animal imaging core, contiguous with a large animal housing satellite, and has already been site-prepped to accommodate the future installation of a new MRI which would allow it to be brought online relatively quickly. Also conveniently nearby are the Southwest National Primate Research Center (SNPRC) and the SFBR that provide non-human primates and other exotic species for imaging at the RIC. Put to use, this new MRI will drive high-caliber translatable research directed at improving our understanding and treatment of human diseases, provide an important training environment and, since its use involves survivable testing, at lesser sacrifice of animal subjects.

描述（由申请人提供）：该提案的目的是寻求资金，以购买将在圣安东尼奥的UT健康科学中心安装的小孔，7T MRI扫描仪（UTHSCSA）。该工具的调试将有助于解决对高分辨率动物MRI的跨机构需求。它将为位于UTHSCSA的区域生物医学学术社区服务，西南生物医学研究基金会（SFBR），奥迪·墨菲纪念退伍军人医院。和UT San Antonio。先进的Bruker Clinscan MR System刚刚出现在市场上，并代表了一项急需的领先技术，该技术采用了高性能的脉冲磁性梯度场和32通道并行的RF Systems。在Siemens Syngo Consol和Ideamri脉冲测序的驱动下，该仪器现在将使用户能够执行诸如动态啮齿动态fMRI和心脏成像之类的苛刻研究。扫描方式产生了以前无法使用我们现有的2T和3T人类MRI无法实现的上空分辨率的较高的时间分辨率，包括解剖学MR显微镜（〜100UM分辨率），BOLD（氧气利用），MR Spectroscopicy，MR Spectroscopicy，Contrast-Felly-Plyfusion MRI（血液流动）和扩散张量张镜头想象（白色物质连接）。尽管该提案最初将为建立良好的NIH调查员提供服务，但这些强大的功能无疑会吸引其他调查人员获取试点数据，以推动新的NIH NIH赠款提交。因为该MRI可以容纳从转基因小鼠到非人类灵长类动物以及尸体人类组织的各种动物大小和物种，所以我们期望产生跨越多个学科的兴趣，例如肿瘤学，衰老，神经和精神病学。我们预计，该新工具将充当产生创新策略来解决复杂假设的催化剂。 RIC是UTHSCSA医学院的部门级单位，其宪章是为基本的临床前和临床研究开发非侵入性成像。它拥有专门用于研究的出色设施。这包括最近扩展其动物成像核心，与大型动物住房卫星相邻，并且已经对现场进行了预测，以适应未来的新MRI安装，从而可以相对较快地将其带到在线上。附近也很方便的是西南国家灵长类动物研究中心（SNPRC）和提供非人类灵长类动物和其他外来物种的SFBR。为了使用，这种新的MRI将推动旨在提高我们对人类疾病的理解和治疗的高素质翻译研究，提供了重要的培训环境，并且由于其使用涉及可生存的测试，以减少动物受试者的牺牲。