PET AND MRI OF MARMOSETS: A PILOT STUDY

狨猴的 PET 和 MRI：一项试点研究

• 批准号: 7716106
• 负责人: MICHAEL DUFF DAVIS
• 金额: $ 0.01万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716106
• 关键词: 5 year old; Age; Aging; Arts; Atlases; Birth; Brain; Callithrix; Callithrix jacchus jacchus; Cebidae; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Fostering; Four-dimensional; Funding; Grant; Human; Institution; Invasive; Life; Longevity; Macaca; Magnetic Resonance Imaging; Maps; Medical Imaging; Methods; Modeling; Motivation; Pilot Projects; Positron-Emission Tomography; Primates; Range; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health; day; senescence; size

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this research is to use state-of-the-art, non-invasive, medical imaging methods to create a 4-dimensional (space and time), multi-variable atlas of the marmoset brain across the entire life-span -from birth, through development and maturation, to senescence -and to map the temporal profiles of derived variables into the temporal profiles of these same variables in humans. The motivation for this undertaking is to foster the development of the marmoset as a practical, primate model of aging. The marmoset is the smallest and shortest-lived new-world monkey, with a median life-span of -6 years. Despite its small size, the marmoset brain is remarkably complex, having all the major cytoarchitectonic regions present in larger, longer-lived, more-commonly studied primates, such as the macaque. In this study we will conduct PET and MR imaging on four common marmosets, ranging in age 1 day old to 5 years old, in order to demonstrate feasibility.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的长期目标是使用最先进的，非侵入性的医学成像方法来创建4维（时空），多变量的Marmoset大脑的多变量地图集，整个生命中，从出生到发育和成熟，衰老，并映射出临时变量的临时变量，以绘制出这些临时变量的临时变量。这项事业的动机是促进马莫斯特作为一种实用的灵长类动物衰老模式的发展。 Marmoset是最小，最短的新猴子，中间寿命为-6年。尽管尺寸很小，但Marmoset的大脑还是非常复杂的，所有主要的细胞结构区域都存在于较大，寿命更长，更熟悉的灵长类动物（例如猕猴）中。在这项研究中，我们将对四个常见的果棒进行PET和MR成像，年龄在1天至5岁之间，以证明可行性。