Module 1: Visual Function Assessment

模块 1：视觉功能评估

• 批准号: 10470148
• 负责人: Sylvia B. Smith
• 金额: $ 19.94万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470148
• 关键词: Address; Age related macular degeneration; Animal Experimentation; Animal Model; Architecture; Center Core Grants; Collaborations; Corneal dystrophy; Development; Diabetic Retinopathy; Disease; Doctor of Philosophy; Electroretinography; Equipment; Evaluation; Eye; Fluorescein Angiography; Funding; Future; Glaucoma; Goals; Hand; Human; Individual; Intervention; Laboratories; Laboratory Personnel; Optical Coherence Tomography; Outcome; Patients; Physiologic Intraocular Pressure; Process; Productivity; Publications; Research Personnel; Research Project Grants; Resolution; Resources; Retina; Retinitis Pigmentosa; Scientist; Services; Structure; System; Testing; Time; Training; Treatment outcome; Vision; Vision research; Visual system structure; clinically relevant; disease natural history; equipment acquisition; image guided; imaging system; in vivo; in vivo imaging; instrument; instrumentation; investigator training; laboratory experience; member; microscopic imaging; novel; response; retinal imaging; slit lamp imaging; tool; Address; Age related macular degeneration; Animal Experimentation; Animal Model; Architecture; Center Core Grants; Collaborations; Corneal dystrophy; Development; Diabetic Retinopathy; Disease; Doctor of Philosophy; Electroretinography; Equipment; Evaluation; Eye; Fluorescein Angiography; Funding; Future; Glaucoma; Goals; Hand; Human; Individual; Intervention; Laboratories; Laboratory Personnel; Optical Coherence Tomography; Outcome; Patients; Physiologic Intraocular Pressure; Process; Productivity; Publications; Research Personnel; Research Project Grants; Resolution; Resources; Retina; Retinitis Pigmentosa; Scientist; Services; Structure; System; Testing; Time; Training; Treatment outcome; Vision; Vision research; Visual system structure; clinically relevant; disease natural history; equipment acquisition; image guided; imaging system; in vivo; in vivo imaging; instrument; instrumentation; investigator training; laboratory experience; member; microscopic imaging; novel; response; retinal imaging; slit lamp imaging; tool

The visual function assessment module allows non-invasive assessment of eye structure and function, which is critical for clinically-relevant studies of the visual system employing animal models. It affords investigators the tools necessary to systematically interrogate normal visual function and the consequences on vision when normal processes go awry. The expertise and instrumentation available in this module exceed resources of individual investigators’ laboratories and provide access to equipment that, if purchased by a single investigator, would rapidly deplete precious resources. The module provides skilled expertise, training and essential, state- of-the-art equipment to perform the following assessments: (1) electroretinography (ERG), (2) optokinetic tracking response (OKR), (3) spectral domain optical coherence tomography (OCT), (4) fundoscopy, (5) fluorescein angiography (FA), (6) slit-lamp biomicroscopy, (7) intraocular pressure (IOP). For ERGs, the module offers the expertise of a highly skilled PhD electrophysiologist who can perform sophisticated retinal function evaluation and it also offers training for investigators in execution of routine ERGs. A PhD level scientist directs the module and provides training for laboratory personnel for other assessments (OCT, FA, OKR etc). Instruments available in this module include the Celeris Fully Integrated High Throughput ERG Testing system, the Phoenix MICRON Ganzfield ERG, the Bioptigen Spectral Domain Ophthalmic Imaging System (Envisu R2200), the image-guided MICRON IV OCT, two Phoenix MICRON IV in vivo high-resolution retinal imaging microscopes for FA and fundoscopy, the Topcon SL-DR slit-lamp and two hand-held tonometers for rapid IOP assessment. These instruments have been widely used by a number of Culver VDI investigators resulting in collaborations and shared publications/presentations that fully justify formalizing these services as a module. Access to this equipment will enhance vision research for established NEI investigators, first-time NEI R01 investigators, and scientists new to the field of vision research. The activities of the core will be achieved through the following aims: Aim 1. Provide core investigators access to state-of-the-art instrumentation for in vivo visual function analysis and in vivo imaging of the visual system. Aim 2. Provide expert technical assistance and training in the use of the shared instrumentation within the module. Aim 3. Maintain module instrumentation in good working condition, manage usage in a manner that will facilitate productivity, collaboration and the development of novel projects that address major sight-threatening diseases.

视觉功能评估模块允许对眼睛结构和功能进行非侵入性评估，即 对于采用动物模型的视觉系统的临床研究至关重要。它为调查人员提供 系统地询问正常视觉功能的必要工具以及对视觉的后果 正常过程出现了。该模块中可用的专业知识和仪器超过 个人调查人员的实验室，并提供对设备的访问权限，如果由单个调查员购买， 将快速复制宝贵的资源。该模块提供熟练的专业知识，培训和基本国家 - 进行以下评估的艺术设备：（1）电视图（ERG），（2）光疗法 跟踪响应（OKR），（3）光谱域光学相干断层扫描（OCT），（4）基础镜检查，（5） 荧光素血管造影（FA），（6）缝隙灯泡生物显微镜，（7）眼内压（IOP）。对于ERG，模块 提供高技能的博士电生理学家的专业知识，可以执行复杂的残留功能 评估，还为调查人员提供了执行常规ERG的培训。博士学位科学家指导 该模块并为实验室人员提供其他评估的培训（OCT，FA，OKR等）。 此模块中可用的仪器包括塞勒斯完全集成的高吞吐量ERG测试系统， Phoenix Micron Ganzfield ERG，Bioptigen光谱域眼科成像系统（ENVISU） R2200），图像引导的微米IV OCT，两个凤凰微米IV体内高分辨率视网膜成像 FA和Fundoscope的显微镜，TopCon SL-DR缝隙灯和两个用于快速IOP的手持式Tonometer 评估。这些仪器已被许多Culver VDI调查人员广泛使用，导致 合作和共享出版物/演示文稿，以充分证明将这些服务作为模块的格式合理。 使用该设备将增强既定的NEI调查人员的视力研究，首次NEI R01 研究人员和视觉研究领域的科学家。核心的活动将通过 以下目的：目标1。为核心调查人员提供体内视觉的最新仪器 视觉系统的功能分析和体内成像。目标2。提供专家技术帮助和 在模块中使用共享仪器的培训。目标3。维护模块仪器 良好的工作条件，以促进生产力，协作和 开发新型项目，这些项目涉及严重的视力疾病。