The Impact of Diabetes on Neuronal, Glial, and Vascular Cells of the Retina

Diabetic retinopathy is the leading cause of blindness in working-aged Americans (1); the seriousness of the disease is underscored by the burgeoning literature in this field. Reviews of pathogenesis and mechanisms of the disease abound. Indeed, a PubMed search of the topic yields more than 14,000 papers dating back to the late 1940s. It is beyond the scope of this chapter to review such a staggering volume of literature and largely unnecessary given the plethora of outstanding reviews on the topic of mechanisms of diabetic retinopathy that have been published in the last decade.

糖尿病视网膜病变是美国劳动年龄人群失明的主要原因（1）；该领域不断涌现的文献凸显了这种疾病的严重性。关于该疾病发病机制的综述比比皆是。实际上，在PubMed上对该主题进行搜索，可得到自20世纪40年代末以来的14000多篇论文。对如此大量的文献进行综述超出了本章的范围，而且鉴于过去十年中已经发表了大量关于糖尿病视网膜病变机制这一主题的优秀综述，这样做也基本没有必要。