2007 Cell Biology of Metals Gordon Research Conference

2007年金属细胞生物学戈登研究会议

• 批准号: 7276348
• 负责人: ANDREW B. DANCIS
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-11 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276348
• 关键词: Address; Biological; Categories; Cells; Cellular Structures; Cellular biology; Chelating Agents; Chloroplasts; Copper; Destinations; Development; Disease; Eukaryotic Cell; Goals; Homeostasis; Ions; Iron; Link; Membrane; Metalloproteins; Metals; Mitochondria; Molecular Chaperones; Organelles; Pathway interactions; Physiological; Proteins; Range; Research; Research Personnel; Scientist; Students; Translations; Zinc; cofactor; intracellular protein transport; programs; protein transport; symposium; trafficking; transcription factor; uptake

DESCRIPTION (provided by applicant): The principal objective of the 2006 Cell Biology of Metals Gordon Conference is to provide a forum for presentation of new developments and for exchanging ideas in this emerging field. The meeting will bring together scientists, ranging from established investigators to graduate students, to present and discuss the most recent advances in eukaryotic cell biology involving copper, iron and zinc ions and the corresponding metalloproteins. The cell biology of metals encompasses the uptake, distribution and use of metals in cells and organelles. Metals are taken up across membranes and are directed to various cellular destinations, ultimately finding their way into the correct metalloproteins. Intricate mechanisms control uptake, distribution, trafficking, and insertion into proteins. Transporters, chelators, metal cofactors, chaperones (classic sense), metallochaperones, transcription factors and translation regulators are involved. The level of complexity equals that of the protein trafficking pathways that have been characterized in modern cell biology. An important goal is to understand how protein trafficking pathways and metal trafficking pathways are integrated and intersect. Other goals are to understand how cells achieve metal ion homeostasis, how cells sense diverse metal ions, and how homeostatic mechanisms for different metal ions are interconnected. Cellular malfunction or disease ensue if any of the steps in metal homeostasis are perturbed, and the meeting will bring out these disease links. The sessions will generally be organized according to cell structure, cutting across metals (Fe, Cu, Zn, Mo) and evolutionary categories. Sessions are planned to address transport of metals into cells, metals in endocytic and secretory compartments, mitochondria and iron, mitochondria and copper, metals in chloroplasts, metal cofactors, metals in global regulatory programs and metal allocation and sensing. The novelty of the Cell Biology of Metals Conference lies in its unique focus on cell biological issues related to metal ions and the focus on multiple physiological ions.

描述（由申请人提供）：2006年金属细胞生物学戈登会议的主要目标是为展示新的发展和在这个新兴领域中交换思想提供论坛。这次会议将汇集科学家，从成熟的研究人员到研究生，介绍和讨论涉及铜，铁和锌离子以及相应的金属蛋白的真核细胞生物学的最新进展。金属的细胞生物学包含细胞和细胞器中金属的摄取，分布和使用。金属在整个膜上都采用，并针对各种细胞目的地，最终将其进入正确的金属蛋白。复杂的机制控制着吸收，分布，运输和插入蛋白质。涉及转运蛋白，螯合剂，金属辅因子，伴侣（经典感），金属伴侣，转录因子和翻译调节剂。复杂性水平等于现代细胞生物学中蛋白质运输途径的水平。一个重要的目标是了解蛋白质运输途径和金属运输途径如何整合并相交。其他目标是了解细胞如何实现金属离子稳态，细胞如何感知多样的金属离子以及如何互连的不同金属离子的稳态机制。如果金属稳态中的任何步骤都受到干扰，会发生细胞功能故障或疾病，并且会议将带来这些疾病联系。 通常将根据细胞结构组织，跨金属（Fe，Cu，Zn，Mo）和进化类别进行切割。计划将金属转移到细胞，内吞和分泌室中的金属，线粒体和铁，线粒体和铜，叶绿体中的金属，金属辅因子，全球调节程序中的金属以及金属分配以及金属分配和感应的金属。金属细胞生物学会议的新颖性在于其独特的重点是与金属离子有关的细胞生物学问题以及对多种生理离子的关注。