Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN)

改善 BRAIN 下一代人类神经影像研究及其他领域的社区健康公平的招募、参与和获取 (REACH for BRAIN)

• 批准号: 10730955
• 负责人: Susie Yi Huang
• 金额: $ 54.02万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730955
• 关键词: Address; Anatomy; BRAIN initiative; Behavior; Biological; Black race; Boston; Brain; Brain imaging; Categories; Cognition; Communities; Community Health; Consensus; Data; Data Element; Data Set; Decision Aid; Dedications; Development; Disease; Education; Enrollment; Ethics; Ethnic Origin; Evaluation; Event; Foundations; Funding; Genetic; Glean; Goals; Guidelines; Health; Human; Human Resources; Imaging technology; Individual; Informed Consent; Intervention; Joints; Journals; Justice; Latinx; Learning; Literature; Magnetic Resonance Imaging; Maps; Measures; Minority Groups; Modeling; Neuronal Plasticity; Neurosciences; Neurosciences Research; Outcome; Ownership; Participant; Pathway interactions; Population Heterogeneity; Process; Professional Organizations; Publications; Race; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Sampling; Science; Shapes; Speed; Structure; Technology; Theory of Change; Tissues; Underrepresented Populations; United States National Institutes of Health; Variant; Work; brain research; clinical application; community engaged research; community engagement; connectome; data sharing; demographics; diversity and inclusion; essentialism; evidence base; health equity; implementation framework; improved; innovative neurotechnologies; interest; member; minority communities; neural; neuroethics; neuroimaging; neurotechnology; next generation; novel; racism; recruit; repository; sociodemographics; symposium; technology development; technology validation; tool; web site; working group

Project Summary / Abstract Although BRAIN 2.0 called for the BRAIN Initiative to “prioritize diversity and inclusion as a fundamental pillar,” research with the human neuroimaging technologies being developed by BRAIN Initiative continues to rely on non-representative convenience samples. This raises neuroethics concerns related to access and justice, and scientific concerns because non-representative samples undermine most key assumptions supporting causal inference in research. Our proposal for Improving Recruitment, Engagement, and Access for Community Health Equity for BRAIN Next-Generation Human Neuroimaging Research and Beyond (REACH for BRAIN) will directly address these ethical and scientific challenges. REACH for BRAIN will utilize community engagement with Black and Latinx stakeholder networks, to co-create evidence-based solutions and ethical guidance to expand the inclusiveness of participation in NIH BRAIN research and human neuroimaging studies more broadly. Aim 1: Utilizing a stakeholder network, Outcome Map, and Theory of Change (ToC) already established in pilot work, and initially targeting recruitment for research with the BRAIN Initiative supported Connectome 2.0 project, community members, neuroscientists, and neuroethics experts will co-develop and implement a targeted, community-led and participant-centered deliverables to increase the participation of underrepresented and minoritized (URM) groups in neuroimaging research. Using Community Engagement Studios, REACH for BRAIN will facilitate bi-directional learning between community members and the research teams, providing local value for the community and creating a foundation for neuroimaging researchers to implement the framework, and engage and recruit motivated participants from URM communities. Initial implementation of the framework will be by Connectome 2.0 researchers at the Martinos Center, to be followed by evaluation and then expansion to additional neuroimaging research projects at MGH and Harvard. Aim 2: Given the fraught history of scientific racism and biological essentialism in brain science, Aim 1 efforts to create appropriately diverse participation in neuroimaging must be accompanied by guidance on how to reliably measure and report on “race,” “ethnicity,” “ancestry,” and related sociodemographic categories. In Aim 2 we will convene an interdisciplinary expert Working Group (WG) to create consensus ethical guidance and proposed data elements for measuring and reporting demographics in more representative neuroscience research, and we will create applied tools: a) a decision-aid for researchers for working with race, ethnicity, and ancestry data in neuroimaging research; (b) an educational tool for community members; and c) a template for neuroscience journal editors on publication guidelines for reporting race in neuroimaging studies. Impact and Deliverables: We will widely disseminate the project’s tools and guidance via: a dedicated website, co-created community events; national public events co-hosted by project partners; roundtables with journal editors; conference presentations and academic publications; and formal submission to the NIH CDE Repository.

项目摘要 /摘要 尽管大脑2.0要求大脑计划“优先考虑多样性和包容性作为基本 支柱，“大脑倡议开发的人类神经影像技术的研究继续 依靠非代表性的便利样本。这引发了与访问和正义有关的神经伦理问题， 和科学问题，因为非代表性样本破坏了支持的大多数关键假设 研究的因果推断。我们改进招聘，参与和社区访问的建议 大脑下一代人神经影像学研究及超越（大脑的范围）的健康公平将 直接解决这些道德和科学挑战。大脑将利用社区参与 使用黑人和拉丁利益相关者网络，共同创建基于证据的解决方案和道德指导 扩大参与NIH脑研究和人类神经影像学研究的包容性。 目的1：利用利益相关者网络，结果图和变更理论（TOC）已建立 试点工作，最初针对招募研究，以支持Connectome 2.0 项目，社区成员，神经科学家和神经伦理学专家将共同开发和实施 针对性，以社区为主导和以参与为中心的可交付成果，以增加代表性不足的参与 和神经成像研究中的少数（URM）组。使用社区参与工作室，伸手去拿 大脑将促进社区成员与研究团队之间的双向学习，从而提供本地 对社区的价值，并为神经影像学者创造基础，以实施该框架， 并吸引并招募来自URM社区的参与者。框架的初步实施 将由Martinos Center的Connectome 2.0研究人员进行，然后进行评估，然后进行扩展 在MGH和哈佛大学的其他神经成像研究项目中。 目的2：鉴于脑科学中科学种族主义和生物本质主义的历史富有创意，目标1努力 要创建适当的潜水员参与神经影像学，必须通过有关如何的指导来实现 可靠地衡量和报告“种族”，“种族”，“祖先”以及相关的社会人口统计学类别。目标 2我们将召集一个跨学科专家工作组（WG），以创建共识的道德指导和 提出的数据元素，用于测量和报告更具代表性的神经科学中的人口统计信息 研究，我们将创建应用工具：a）研究人员的决策AID，用于与种族，种族和种族合作和 神经影像研究中的祖先数据； （b）针对社区成员的教育工具； c）模板 神经科学杂志编辑有关神经影像学研究报告竞赛的出版指南。影响和 可交付成果：我们将通过以下方式广泛传播项目的工具和指导：专用网站，共同创建 社区活动；由项目合作伙伴共同主持的国家公共活动；带日记编辑的圆桌会议； 会议演讲和学术出版物；并正式提交给NIH CDE存储库。