Amacrine Cell Circuitry Mediating Visual Function

无长突细胞回路介导视觉功能

基本信息

批准号：
7228806
负责人：
FRANK S WERBLIN
金额：
$ 35.36万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-01-01 至 2007-11-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Our deepest understanding of retinal activity has been derived from studies that show how identified amacrine cell types mediate specific visual functions. Saccadic suppression and figure-ground separation by the polyaxonal amacrine cells, directional selective movement detection by the starburst amacrine cells, and the processing of rod vision by the All amacrine cells are examples of sophisticated function mediated by well-defined retinal circuitry involving specific amacrine cell types. The strategy in those studies was to determine how excitatory and inhibitory signals generated by amacrine cells are integrated to form meaningful retinal activity. There exist an additional two dozen amacrine cells in the retina whose morphology and stratification has been well defined, but whose visual functional roles still remain obscure. It is the goal of this proposal to investigate the visual functional role of many of these less defined amacrine cells. Our strategy is to utilize our recent studies of ganglion cell function that have defined a dozen different "feature detectors" formed by the neatly stratified dendrites of a dozen different ganglion cell types distributed throughout the depth of the inner plexiform layer. These studies define the space, time, stratification and phase properties of excitation and inhibition arriving at the dendrites of each ganglion cell type. The inhibitory components of these responses reflect the space, time, stratification and phase properties of different amacrine cell types whose processes costratify with the dendrites of each ganglion cell type. We will record from specific amacrine cell types in retinal slices and correlate their space time phase and stratification properties with the inhibitory properties of the ganglion cells with which they costratify. Through this correlation process we hope to be able to describe the role of specific amacrine cells in generating different components of visual function.

描述（由申请人提供）：我们对视网膜活性的最深刻理解是从研究中得出的，这些研究表明了鉴定的无链酰胺细胞类型如何介导特定的视觉功能。通过多轴测主持链氨酸细胞的抑制作用和图形分离，星爆脉爆肿瘤细胞的定向选择运动检测，以及所有无链无链肌细胞对ROD视觉的处理，是由涉及特定特定的无藻氨酸细胞类型的良好定义的视网膜电路介导的复杂功能的实例。这些研究中的策略是确定无聚氨酯细胞产生的兴奋性和抑制信号如何整合以形成有意义的视网膜活性。视网膜中还有额外的二十二藻细胞，其形态和分层已得到很好的定义，但其视觉功能作用仍然晦涩难懂。该提案的目的是研究许多较少定义的无链氨酸细胞的视觉功能作用。我们的策略是利用我们最近对神经节细胞功能的研究，该研究定义了由十二个不同的神经节细胞类型分布在整个丛生层深度的十二个不同的神经节细胞类型的整齐的树突形成的不同的“特征探测器”。这些研究定义了激发和抑制的空间，时间，分层和相位特性到达每种神经节细胞类型的树突。这些响应的抑制成分反映了不同的无4akine细胞类型的空间，时间，分层和相特性，其过程与每种神经节细胞类型的树突形成。我们将从视网膜切片中的特定无长血性细胞类型中记录，并将其时空和分层特性与它们所构成的神经节细胞的抑制特性相关联。通过这个相关过程，我们希望能够描述特定的无长束细胞在产生视觉功能不同组成部分中的作用。