METABOLISM OF GLUTAMINE IN NEWBORN INFANTS

新生儿谷氨酰胺的代谢

• 批准号: 7202708
• 负责人: SATISH C KALHAN
• 金额: $ 0.11万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7202708
• 关键词: clinical research; human subject

DESCRIPTION: (provided by applicant) The purpose of this application to seek funding for the renewal of the General Clinical Research Center (GCRC) at Case Western Reserve University (CWRU) School of Medicine. The main GCRC is located at University Hospitals of Cleveland with a satellite at MetroHealth Medical Center (MHMC). In 2002, the GCRC supported 166 protocols for 90 principal investigators representing multiple schools, departments and divisions of CWRU, the Department of Cell Biology at the Cleveland Clinic Foundation, and the Department of Nutrition and Exercise Physiology at Cleveland State University. As a research institute, CWRU's School of Medicine has maintained a tradition of national leadership, including claim to 12 Nobel laureates among its alumni (5) and faculty (7). There are 1,493 full time faculty in the medical school. In 2001, CWRU researchers were funded over $174,000,000 by NIH. These awards include major funding for research in cancer, AIDS, diabetes, cystic fibrosis, hypertension, TB, skin diseases, Alzheimer's disease, cartilage regeneration, airway diseases, neonatal and adult metabolism, functional electric stimulation, perinatal medicine, and genetics defects of various types among others. Fifty-seven CWRU researchers were awarded more than $1 million in NIH support in 2002. In 2002, CWRU ranked 16th among the nations 126 medical schools in NIH support. Fifteen of the school's departments ranked in the top 20 of the corresponding departments. Compared to the last five year renewal, there has been a 17% increase in the number of GCRC investigators and 81% increase in number of protocols utilizing the GCRC which resulted in a 97% increase in the number of publications (from 201). The major areas of research include: 1. Biochemical and molecular enhancement of cancer chemotherapy. 2. Electronic restoration of movement in spinal cord injury and stroke. 3. Molecular biology and treatment of cystic fibrosis. 4. Carbohydrate and protein metabolism in pregnancy. 5. Epidemiology, genetics, and pathophysiology of sleep-disordered breathing. 6. Pathophysiology and renal outcomes of human hypertension. 7. Factors affecting feto-placental growth and development. 8. Pathophysiology and treatment of HIV diseases.

描述：（由申请人提供）本申请的目的是为凯斯西部储备大学（CWRU）医学院的一般临床研究中心（GCRC）寻求资金。主要GCRC位于克利夫兰大学医院，并在Metrohealth医疗中心（MHMC）拥有卫星。 2002年，GCRC为90名主要调查人员提供了166项协议，代表CWRU的多个学校，部门和部门，克利夫兰诊所基金会的细胞生物学系以及营养部和 克利夫兰州立大学运动生理学。作为研究机构，CWRU的医学院一直保持着国家领导的传统，其中包括在其校友（5）和教职员工（7）中声称诺贝尔奖获得者。医学院有1,493个全职教师。 2001年，CWRU研究人员由NIH资助了174,000,000美元。这些奖项包括用于癌症，艾滋病，糖尿病，囊性纤维化，高血压，结核病，皮肤疾病，阿尔茨海默氏病，软骨再生，气道疾病，新生儿和成人代谢，功能性电刺激，衰减医学和各种类型的遗传学等的主要资金。 2002年，57名CWRU研究人员获得了超过100万美元的NIH支持。2002年，CWRU在NIH支持NIH支持的126届医学院中排名第16位。学校部门中有15个在相应部门的前20名中排名。与过去五年的续约相比，GCRC研究人员的数量增加了17％，利用GCRC的协议数量增加了81％，这导致出版物数量增加了97％（2011年）。研究的主要领域包括：1。癌症化疗的生化和分子增强。 2。电子恢复脊髓损伤和中风的运动。 3。分子生物学和囊性纤维化的治疗。 4。怀孕中的碳水化合物和蛋白质代谢。 5。睡眠呼吸的流行病学，遗传学和病理生理学。 6。人类高血压的病理生理和肾脏结局。 7。影响胎儿生长和发育的因素。 8。艾滋病毒疾病的病理生理和治疗。