METABOLISM OF METHIONINE IN THE NEWBORN INFANT

新生儿蛋氨酸的代谢

• 批准号: 7378013
• 负责人: SATISH C KALHAN
• 金额: $ 0.83万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378013
• 关键词: METABOLISM; METHIONINE; NEWBORN; INFANT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to quantify the kinetics and metabolism of methionine (transsulfuration pathway), a sulfur containing essential amino acid, in healthy full term babies and in low birth weight infants. Healthy full term babies will be recruited from the normal newborn nursery while low birth weight (premature) infants will be recruited from the Neonatal Intensive Care Unit. By using stable, non-radioactive isotopic tracers of methionine, phenylalanine and urea, the investigators propose to quantify the kinetics of methionine and its relation to whole body protein breakdown (measured by phenylalanine Ra) and whole body rate of protein oxidation (measured by production of urea). In full term infants, after a three-hour basal study, the effect of enterally administered nutrients (formula) on the above parameters will be examined. The total duration of study will be seven hours: three hours basal and four hours of response to intermittent (every 30 minute) feeds. Respiratory calorimetry measurements will be done at periodic intervals in term infants. Blood samples from indwelling venous cannula will be drawn at periodic intervals. The LBW infants will be studied while they are receiving parenteral amino acid at 3.0 g/kg/d for at least 24 hours and not enterally fed. The studies are significant in that they will generate important data which may provide the rationale for supplementation (or not) of cysteine (sulfur amino acid, formed from methionine) in the newborn infant.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的目的是量化蛋氨酸的动力学和代谢（硫化途径），一种含有必需氨基酸的硫，健康的完整婴儿和低出生体重婴儿。 健康的完整婴儿将从正常的新生儿托儿所招募，而低出生体重（早产）将从新生儿重症监护病房招募。通过使用蛋氨酸，苯丙氨酸和尿素的稳定的非放射性同位素示踪剂，研究者建议量化蛋氨酸的动力学及其与全身蛋白质分解的关系（通过苯丙氨酸RA）和蛋白质氧化的全身速率（通过尿素生产测量）。在全年的婴儿进行三小时的基础研究之后，将检查肠内给药营养素（公式）对上述参数的影响。研究的总持续时间为七个小时：三个小时的基础和对间歇性（每30分钟）提要的四个小时的响应。呼吸量热法测量将在期限婴儿中定期进行。将定期抽取留置静脉套管的血液样本。 LBW婴儿在3.0 g/kg/d接受肠胃外氨基酸至少24小时内接受肠胃外氨基酸，而肠道含量为24小时。 研究很重要，因为它们将产生重要的数据，这可能为新生婴儿中的半胱氨酸（由甲氨酸形成）补充（或不补充）的基本原理。