COGNITIVE EFFECTS OF ALCOHOL IN PERI-ADOLESCENT MONKEYS

酒精对青春期猴子认知的影响

• 批准号: 7006982
• 负责人: MICHAEL A. TAFFE
• 金额: $ 17.18万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-05 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7006982
• 关键词: Macaca mulatta; adolescence (12-20); alcoholic beverage consumption; alcoholism /alcohol abuse; attention; behavior test; behavioral /social science research tag; cognition; drug withdrawal; learning; memory; psychomotor function

DESCRIPTION (provided by applicant): Recreational overuse of alcohol among adolescent populations remains a significant and growing public health concern. Surveys report that 10% of eighth graders and up to a third of high school seniors consume binge quantities of alcohol on at least a biweekly basis. Heavy drinking during this critical period of formal education and significant brain development may pose serious risk for later intellectual and cognitive function. The proposed studies will develop a novel nonhuman primate model to evaluate the consequences of heavy drinking during adolescence task acquisition and performance in a range of cognitive domains. The Aims under investigation are 1) To determine if chronic oral alcohol intake slows acquisition of a battery of cognitive and behavioral tests in peri-adolescent monkeys; 2) To determine the cognitive and behavioral effects of withdrawal from chronic alcohol exposure; and 3) To determine if a history of chronic oral alcohol intake alters monkeys' cognitive and behavioral sensitivity to challenge with specific psychoactive compounds. Peri-adolescent monkeys will be trained on a battery of tests which probe learning, memory, attention and motor functions. A flavorant-fade procedure will be used to generate consistent, high levels of alcohol drinking in the experimental group which will be allowed to orally self-administer alcohol (M-F) throughout the 18 month test acquisition period. Radiotelemetric measurement of circadian patterns of body temperature and locomotor activity, and cerebrospinal fluid monoamine / metabolite concentrations will be used as correlates for the behavioral measures. Access to alcohol will be discontinued following acquisition of all behavioral tests to evaluate possible effects of withdrawal on the behavioral and physiological measures. Acute doses of psychoactive compounds will be employed to probe possible persisting behavioral sensitivities to serotonergic, dopaminergic, GABAergic or glutamatergic challenge. This exploratory study will provide evidence regarding the risks posed to cognition by heavy alcohol drinking in the peri-adolescent period.

描述（由申请人提供）： 在青少年人口中，娱乐性过度使用酒精仍然是一个重要且日益增长的公共卫生问题。调查报告说，至少每两周一次，有10％的八年级学生和最多三分之一的高中生食用狂暴的酒精。在这个正规教育和大脑发展的重要时期，大量饮酒可能会对以后的智力和认知功能造成严重的风险。拟议的研究将开发一种新型的非人类灵长类动物模型，以评估在一系列认知领域的青春期任务习得和表现中大量饮酒的后果。正在调查的目的是1）确定慢性口服酒精摄入是否会减慢围场猴子中一系列认知和行为测试的收购； 2）确定从慢性酒精暴露中退出的认知和行为影响； 3）确定慢性口服酒精摄入量的史是否改变了猴子的认知和行为敏感性，以挑战特定的精神活性化合物。青春期猴子将在探测学习，记忆，注意力和运动功能的一系列测试中训练。在整个18个月的测试习得期间，将使用一种调味剂输入程序来在实验组中产生一致的高水平饮酒剂。射节体测量体温和运动活性的昼夜节律模式以及脑脊液单胺 /代谢物浓度将用作行为措施的相关性。获得所有行为测试后，将停止使用酒精，以评估戒断对行为和生理措施的可能影响。急性剂量的精神活性化合物将用于探测对血清素能，多巴胺能，GABA能或谷氨酸能挑战的持续行为敏感性。这项探索性研究将提供证据，表明在青春期期间，大量饮酒对认知带来的风险。