Cannabinoid regulation of cognition

大麻素对认知的调节

• 批准号: 8793181
• 负责人: MICHAEL A. TAFFE
• 金额: $ 70.64万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8793181
• 关键词: 21 year old; Acute; Admission activity; Adult; Adverse effects; Animals; Attenuated; Behavioral; CNR1 gene; Cannabidiol; Cannabinoids; Cannabis; Chronic; Cognition; Cognitive; Complex; Dependence; Development; Discrimination Learning; Drug usage; Exposure to; Goals; Heroin; Human; Impaired cognition; Individual; Intoxication; Laboratories; Laws; Macaca mulatta; Marijuana; Marijuana Dependence; Marijuana Smoking; Measures; Mediating; Medical; Medical Marijuana; Memory; Modeling; Monkeys; Motor; Multiple Sclerosis; Neuropsychological Tests; Oral mucous membrane structure; Pharmaceutical Preparations; Proliferating; Psychotropic Drugs; Public Health; Regulation; Reporting; Reversal Learning; Rodent; Route; Sativex; Selection Bias; Serotonin; Short-Term Memory; Symptoms; Testing; Tetrahydrocannabinol; Therapeutic; United States Department of Veterans Affairs; Veterans; Work; cocaine use; cognitive function; improved; marijuana use; meetings; nonhuman primate; preclinical study; protective effect; public health relevance; recreational drug use; synthetic drug; trend; twelfth grade

DESCRIPTION (provided by applicant): Cannabis remains the most popular illicit psychoactive drug used in the US. Some 70-80 percent of 40- 50 year olds have tried it at least once in their lifetime and 18-19 percent of 18-21 years olds have used cannabis in the past month. There are more people in the US who meet criteria for cannabis dependence than have used cocaine in the past month or ever tried heroin; it is of further concern that the use of cannabis under medical marijuana laws continues to expand in the US as dispensaries proliferate. Trends for increased medical use may continue following, e.g., findings that smoked marijuana or a combined-cannabinoid spray can improve symptoms in multiple sclerosis. Studies have shown that acute intoxication with cannabis impairs cognitive function, however cannabidiol (CBD), a constituent of some cannabis strains, may provide some protection from the acute and lasting detrimental effects of cannabis. The studies in this project seek to determine if CBD can attenuate specific cognitive disruptions caused by D9-tetrahydrocannabinol (THC), using a nonhuman primate model. A battery of tests shown sensitive to THC will be used to determine if CBD can block the effects of both acute and chronic administration of THC. The goal is to determine the extent to which CBD might be used to moderate effects of THC in the therapeutic setting, although there are also implications for the recreational user.

描述（由申请人提供）：大麻仍然是美国最流行的非法精神活性药物。大约 70-80% 的 40-50 岁人群一生中至少尝试过一次大麻，18-19% 的 18-21 岁人群在过去一个月内使用过大麻。在美国，符合大麻依赖标准的人数比过去一个月吸食可卡因或尝试过海洛因的人数还多；更令人担忧的是，随着药房激增，美国根据医用大麻法使用大麻的情况持续扩大。医疗用途增加的趋势可能会持续下去，例如，发现吸食大麻或组合大麻素喷雾剂可以改善多发性硬化症的症状。研究表明，大麻急性中毒会损害认知功能，但某些大麻品种的成分大麻二酚 (CBD) 可能会提供一定的保护，免受大麻的急性和持久有害影响。该项目的研究旨在使用非人类灵长类动物模型来确定 CBD 是否可以减轻 D9-四氢大麻酚 (THC) 引起的特定认知障碍。一系列对 THC 敏感的测试将用于确定 CBD 是否可以阻止 THC 的急性和慢性给药的影响。目标是确定 CBD 在治疗环境中可在多大程度上减轻 THC 的影响，尽管这对娱乐使用者也有影响。