Cannabinoid regulation of cognition

大麻素对认知的调节

• 批准号: 8484251
• 负责人: MICHAEL A. TAFFE
• 金额: $ 50.48万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8484251
• 关键词: 21 year old; Acute; Admission activity; Adult; Adverse effects; Animals; Attenuated; Behavioral; Cannabidiol; Cannabinoids; Cannabis; Chronic; Cognition; Cognitive; Complex; Dependence; Development; Discrimination Learning; Drug usage; Exposure to; Goals; Heroin; Human; Impaired cognition; Individual; Intoxication; Laboratories; Laws; Macaca mulatta; Marijuana; Marijuana Dependence; Marijuana Smoking; Measures; Mediating; Medical; Memory; Modeling; Monkeys; Motor; Multiple Sclerosis; Neuropsychological Tests; Oral mucous membrane structure; Pharmaceutical Preparations; Proliferating; Psychotropic Drugs; Public Health; Regulation; Reporting; Reversal Learning; Rodent; Route; Sativex; Selection Bias; Serotonin; Short-Term Memory; Symptoms; Testing; Tetrahydrocannabinol; Therapeutic; United States Department of Veterans Affairs; Veterans; Work; cocaine use; cognitive function; improved; meetings; nonhuman primate; preclinical study; protective effect; public health relevance; recreational drug use; synthetic drug; trend; twelfth grade

DESCRIPTION (provided by applicant): Cannabis remains the most popular illicit psychoactive drug used in the US. Some 70-80 percent of 40- 50 year olds have tried it at least once in their lifetime and 18-19 percent of 18-21 years olds have used cannabis in the past month. There are more people in the US who meet criteria for cannabis dependence than have used cocaine in the past month or ever tried heroin; it is of further concern that the use of cannabis under medical marijuana laws continues to expand in the US as dispensaries proliferate. Trends for increased medical use may continue following, e.g., findings that smoked marijuana or a combined-cannabinoid spray can improve symptoms in multiple sclerosis. Studies have shown that acute intoxication with cannabis impairs cognitive function, however cannabidiol (CBD), a constituent of some cannabis strains, may provide some protection from the acute and lasting detrimental effects of cannabis. The studies in this project seek to determine if CBD can attenuate specific cognitive disruptions caused by D9-tetrahydrocannabinol (THC), using a nonhuman primate model. A battery of tests shown sensitive to THC will be used to determine if CBD can block the effects of both acute and chronic administration of THC. The goal is to determine the extent to which CBD might be used to moderate effects of THC in the therapeutic setting, although there are also implications for the recreational user.

描述（由申请人提供）：大麻仍然是美国使用的最流行的非法精神活性药物。 40-50岁的年轻人中，约有70-80％在他们的一生中至少尝试过一次，而18-21岁的年轻人中有18-19％在过去一个月中使用了大麻。在美国，符合大麻依赖标准的人要比过去一个月或尝试过海洛因的人多。进一步关注的是，随着药房的繁殖，根据医用大麻法的使用继续扩展。随着医疗用途的增加趋势，例如，烟熏大麻或合并 - 大麻素喷雾的发现可以改善多发性硬化症的症状。研究表明，用大麻的急性中毒会损害认知功能，但是大麻二酚（CBD）是某些大麻菌株的组成部分，可能会提供一些保护，以避免大麻的急性和持久的有害作用。该项目中的研究旨在确定CBD是否可以使用非人类灵长类动物模型来减轻由D9四氢大麻酚（THC）引起的特定认知破坏。对THC敏感的一系列测试将用于确定CBD是否可以阻止THC的急性和慢性给药的影响。目的是确定可以使用CBD在治疗环境中适度THC影响的程度，尽管对娱乐用户也有影响。