Adolescent Alcohol Use: Developmental & Long-Term Risks

青少年饮酒：发育

• 批准号: 6845698
• 负责人: ALLYSON J BENNETT
• 金额: $ 28.7万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6845698
• 关键词: Macaca mulatta; adolescence (12-20); alcoholic beverage consumption; alcoholism /alcohol abuse; behavior test; behavioral /social science research tag; blood chemistry; cognition; disease /disorder proneness /risk; growth /development; high risk behavior /lifestyle; learning; longitudinal animal study; magnetic resonance imaging; memory; social behavior

DESCRIPTION (provided by applicant): Growing evidence suggests that adolescent alcohol exposure has deleterious effects on physiological and behavioral development and significantly increases vulnerability to excessive alcohol consumption in adulthood. The proposed studies broadly aim to characterize the adolescent developmental time period as a unique window of risk for alcohol-induced damage and to investigate whether abstention from alcohol in adolescence is protective, increasing resilience to administration in macaque monkeys that reliably produces a pattern of excessive ethanol consumption. We propose to use this model to investigate the effects of a binge-pattern alcohol exposure during the adolescent period on physiological and behavioral development, and subsequently, as a risk factor or increased alcohol consumption during adulthood. By using a longitudinal design, as well as between-groups comparison of animals exposed to alcohol during adolescence, animals first exposed during adulthood, and abstinent animals never exposed to alcohol, we will be able to examine potential additive or interactive effects of adolescent alcohol exposure in order to determine whether the outcome of adult exposure is altered by previous alcohol experience. The extent and longevity of alcohol effects will be evident from group comparisons after extended adult alcohol consumption. Finally, recovery from alcohol-induced damage will be assessed during a wash-out period. Recovery from alcohol-induced damage will be assessed during a wash-out period followed by opportunity to resume drinking. The final, extended phase of alcohol self-administration will characterize abusive patterns of alcohol intake that endure through a significant portion of adult life.

描述（由申请人提供）： 越来越多的证据表明，青少年酒精暴露对生理和行为发展产生有害影响，并显着增加了成年期过度饮酒的脆弱性。拟议的研究广泛地旨在将青少年发育时期表征为饮酒引起的损害风险的独特风险，并调查青春期戒烟是否具有保护性，从而提高了对猕猴的弹药的弹性，从而可靠地产生过度乙醇消耗的模式。我们建议使用此模型来研究青少年期间暴饮暴食对生理和行为发展的影响，然后作为危险因素或成年期间的饮酒量增加。通过使用纵向设计，以及青春期暴露于酒精的动物的组间比较，在成年期间首次暴露于动物，而避免的动物从未暴露于酒精中，我们将能够检查青少年酒精暴露的潜在添加性或交互作用，以确定以前的酒精经验会改变成人的结果。在成人饮酒后的群体比较中可以明显看出酒精效应的程度和寿命。最后，将在洗涤期间评估酒精引起的损害。从酒精引起的损害中恢复，将在洗涤期间进行评估，然后有机会恢复饮酒。酒精自我管理的最后一个扩展阶段将表征滥用酒精摄入的模式，这些模式在大部分成人生活中忍受。