CLINICAL CORE

临床核心

• 批准号: 6933567
• 负责人: Donald L. Bliwise
• 金额: $ 22.91万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933567
• 关键词: Alzheimer' s disease; biomedical facility; brain disorder diagnosis; clinical research; cognition disorders; comorbidity; comprehensive care; health care quality; human subject; neuropsychological tests; patient /disease registry; psychometrics

The Clinical Core of the Emory Alzheimer's Disease Center (ADC) provides state-of-the-art diagnostic assessment of AD and other dementias, with a special emphasis on comorbid conditions that contribute to impaired cognition. The primary mission of the Core is to afford access to well-characterized patient pools with which to conduct innovative clinical and basic research projects. The Emory ADC has many unique features, including a large, ethnically diverse patient population and investigators with expertise in clinical and basic science related to a broad range of dementing illnesses. In addition, there is active involvement of established investigators with expertise in other conditions known to impair cognition in the aged population. An implicit component of the Clinical Core is the broadening notion of Mild Cognitive Impairment (MCI). A major challenge is to identify features that will predict which cases of MCI will progress to AD, or other dementing disorders, including dementia with Lewy bodies, vascular dementia, and Parkinson's disease. In addition, a substantial body of literature indicates that conditions, such as depression, cardiac disease, diabetes, hypertension, and sleep apnea, which are highly prevalent in the geriatric population, exert strong independent influences on cognitive function, and they can accelerate the progression of degenerative neurologic diseases. Through the activities of the Clinical Core and its interactions with other components of the Emory ADC, we will achieve three specific aims: 1) to evaluate cases of MCI, AD, and other dementias by systematic collection and evaluation of neurological and neuropsychological measures and examination of medical comorbidities; 2) to enhance the care of patients and families through comprehensive clinical services, education, and access to promising clinical trials and other research activities; and 3) to support and promote research studies by sharing carefully and systematically collected data from registry participants, including clinical evaluations, family histories, DMA, and other biological materials.

阿尔茨海默氏病中心（ADC）的临床核心提供了对AD和其他痴呆症的最新诊断评估，并特别强调了合并症，这有助于认知受损。核心的主要任务是为可以使用创新的临床和基础研究项目的特征性的患者池提供。 Emory ADC具有许多独特的特征，包括大型，种族多样化的患者人群以及具有与广泛痴呆疾病有关的临床和基础科学专业知识的研究者。此外，在已知损害老年人群认知的其他条件下，已有专业知识的已建立研究人员积极参与。 临床核心的一个隐式组成部分是拓宽了轻度认知障碍的概念（MCI）。一个主要的挑战是确定将预测哪些MCI病例将进展为AD的特征，或其他痴呆症，包括Lewy身体，血管性痴呆和帕金森氏病的痴呆症。此外，大量文献表明，抑郁症，心脏病，糖尿病，高血压和睡眠呼吸暂停等疾病在老年人群中非常普遍，对认知功能产生了强烈的独立影响，并且可以加快变性神经学疾病的进展。通过临床核心的活动及其与Emory ADC的其他组件的相互作用，我们将实现三个具体目标：1）评估MCI，AD和其他痴呆症的病例 通过系统收集和评估神经和神经心理学措施以及医学合并症的检查； 2）通过全面的临床服务，教育以及获得有前途的临床试验和其他研究活动来增强患者和家庭的护理； 3）通过仔细和系统地收集了注册表参与者的数据，包括临床评估，家庭历史，DMA和其他生物学材料，来支持和促进研究。