Biomarkers of Aging in the Bay Area Sleep Cohort

湾区睡眠队列中的衰老生物标志物

• 批准号: 6680558
• 负责人: Donald L. Bliwise
• 金额: $ 30.41万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6680558
• 关键词: aging; biomarker; blood pressure; clinical research; disease /disorder proneness /risk; electrocardiography; epidemiology; heart function; human old age (65+); human subject; longitudinal human study; neuropsychological tests; polysomnography; questionnaires; respiratory function; sleep apnea; spirometry

DESCRIPTION (provided by investigator): Sleep Disordered Breathing (SDB) is a common condition in the elderly population but its relationship to health in old age remains uncertain and its natural history is virtually unknown. The proposed longitudinal study will continue a previously initiated follow-up of a cohort of elderly subjects studied with physiologic sleep recordings (polysomnography). This unique group of 256 individuals, initially recruited and evaluated with in-lab polysomnography between 1974 and 1985 and followed prospectively since that time, is referred to as the Bay Area Sleep Cohort (BASC). A substantial number of BASC subjects already have undergone two occasions of polysomnographic measurement (n = 173), whereas as a smaller subgroup has been studied previously on three occasions (n = 76). Surviving BASC subjects (n = 137, X age = 81.2) will be re-recorded in a joint effort between investigators at Emory University in Atlanta, Georgia and SRI International of Menlo Park, California. These two institutions, and the Principal Investigator and Co-Principal Investigator, respectively, have a ten-year history of working on field studies of SDB in elderly populations in different geographic regions in the United States. The application requests funds to locate all surviving members of BASC as well as to: follow-up these individuals using current state-of-the-art ambulatory polysomnographic technology; perform comprehensive evaluations of health, including measures of neurobehavioral, pulmonary, and cardiovascular function among those surviving members; archive and summarize existing polysomnographic recordings; and to analyze data longitudinally by calculating each individual's rate of change in their characteristic levels of SDB. Individual differences in rates of change will be related to changes in neurobehavioral, pulmonary, and cardiovascular function over time. "Families" of regression lines will compare stage-specific rates to examine how changes in sleep architecture parallel development of SDB at follow-up. These results will allow elucidation of SDB as a potentially sensitive aging biomarker as well as characterizing how this index of physiologic age relates to other better recognized biomarkers of aging. The early establishment of this cohort and the absolute scarcity of information on population-based data on the progression of SDB present a unique opportunity to discover how human sleep may reflect fundamental alterations in aging processes.

描述（调查员提供）：睡眠失调的呼吸（SDB）是老年人口中的常见状况，但其与老年人的关系仍然不确定，并且其自然历史实际上是未知的。拟议的纵向研究将继续进行先前开始的随访，对研究的一系列具有生理睡眠记录的老年受试者（多摄影）。这一独特的256个人最初在1974年至1985年间通过LAB多脑线仪进行了招募和评估，自那时以来一直被认为是湾区睡眠队列（BASC）。大量的BASC受试者已经经历了两次多渗透学测量测量（n = 173），而作为较小的亚组，先前已在三次中进行了研究（n = 76）。尚存的BASC受试者（n = 137，X Age = 81.2）将在亚特兰大，乔治亚州埃默里大学的调查人员与加利福尼亚州门洛公园的Sri International之间进行联合录制。这两个机构以及主要研究人员和联合校长研究者在美国不同地理区域的老年人口进行SDB的现场研究历史上有十年的历史。该申请要求资金找到BASC的所有幸存成员，以及以下内容：使用当前最先进的卧床多聚疗法技术跟进这些人；对健康的人进行全面评估，包括在幸存成员中对神经行为，肺和心血管功能的衡量；档案并总结现有的多聚会记录；并通过计算每个人的SDB特征水平的变化率来纵向分析数据。随着时间的流逝，变化率的个体差异将与神经行为，肺和心血管功能的变化有关。回归线的“家族”将比较特定于阶段的速率，以检查SDB随访时的睡眠体系结构的变化如何平行发展。这些结果将允许将SDB阐明为潜在敏感的衰老生物标志物，并表征这种生理年龄指标与其他识别型衰老的其他更好的生物标志物。该队列的早期建立以及有关SDB进展的基于人群数据的信息的绝对稀缺性提供了一个独特的机会，以发现人类睡眠如何反映衰老过程中的基本变化。