COGNITIVE REHABILITATION IN ALZHEIMER'S DISEASE

阿尔茨海默病的认知康复

• 批准号: 6932635
• 负责人: DAVID LOEWENSTEIN
• 金额: $ 10.9万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932635
• 关键词: Alzheimer' s disease; association learning; behavioral /social science research tag; caregivers; cholinesterase inhibitors; cognition disorders; combination therapy; coping; human subject; human therapy evaluation; longitudinal human study; mental disorder chemotherapy; neuropsychological tests; pathology; patient oriented research; psychological aspect of aging; psychological stressor; psychotherapy; rehabilitation; short term memory

Cognitive rehabilitation has been shown to be effective in treating a wide variety of neurological disorders including traumatic brain injury and stroke. Until recently, there has been limited data examining the effects of cognitive rehabilitation in Alzheimer's Disease (AD). Results from our recent NIH-funded Cognitive Rehabilitation Pilot Trial demonstrate that an integrated program that employs specific techniques such as spaced retrieval, procedural learning and dual cognitive support significantly improves and maintains gains in performance on a number of cognitive tasks among mildly impaired AD patients who are on a stable dose of a cholinesterase inhibitor. Given the promise of newer and more effective pharmacological agents in the future, these findings have important implications for optimizing and maintaining the patient's cognitive and functional independence. The proposed study represents an attempt to compare the efficacy of an improved cognitive rehabilitation program incorporating prospective memory training among mildly impaired AD patients on a cholinesterase inhibitor versus mildly impaired patients on a cholinesterase inhibitor alone. A unique aspect of this study is to determine the extent to which maintenance sessions can maximally prolong postintervention cognitive rehabilitation treatment gains. In addition to the direct benefit to AD patients, the interventions will be evaluated with regards to their impact on caregiver's distress and perceived burden.

认知康复已被证明可以有效治疗多种神经系统疾病，包括创伤性脑损伤和中风。直到最近，关于认知康复对阿尔茨海默病 (AD) 的影响的数据还很有限。我们最近由 NIH 资助的认知康复试点试验的结果表明，采用间隔检索、程序学习和双重认知支持等特定技术的综合计划可显着改善并维持轻度受损 AD 患者在许多认知任务上的表现。正在服用稳定剂量的胆碱酯酶抑制剂。鉴于未来更新、更有效的药物制剂的前景，这些发现对于优化和维持患者的认知和认知能力具有重要意义。 功能独立。拟议的研究尝试比较改进的认知康复计划（结合前瞻性记忆训练）对使用胆碱酯酶抑制剂的轻度受损 AD 患者与仅使用胆碱酯酶抑制剂的轻度受损患者的疗效。这项研究的一个独特之处是确定维持课程可以在多大程度上最大限度地延长干预后认知康复治疗的收益。除了对 AD 患者的直接益处外，还将评估干预措施对护理人员的痛苦和感知负担的影响。