Semantic Interference and Early Detection of Dementia
语义干扰和痴呆症的早期检测
基本信息
- 批准号:7228075
- 负责人:
- 金额:$ 40.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-06-01 至 2010-04-30
- 项目状态:已结题
- 来源:
- 关键词:AllelesAlzheimer&aposs DiseaseApolipoprotein EBenignBrainCaucasiansCaucasoid RaceClinicalCognitiveCommunitiesConditionDataDegenerative DisorderDelayed MemoryDementiaDetectionDevelopmentDiagnosisDiseaseDisease ProgressionDoctor of PhilosophyEarly DiagnosisElderlyEventExhibitsFutureGenotypeHispanicsImpaired cognitionImpairmentIndividualInvestigationLaboratoriesLanguageMeasuresMemoryMemory DisordersMemory impairmentNeuropsychological TestsNot Hispanic or LatinoPatientsPerformancePersonsPilot ProjectsPopulations at RiskPrevalencePurposeRateRiskScoreSemanticsSensitivity and SpecificitySeriesStagingTestingTimeVisuospatialWorkbasecomparativeexecutive functionforgettinggenetic risk factorheuristicsinstrumentmild neurocognitive impairmentneuropsychologicalnovelolder patientperformance testsprospective memoryskills
项目摘要
DESCRIPTION (provided by applicant): The prevalence of memory disorders increases with advancing age, presenting a challenge for clinicians who must differentiate a benign condition from a serious and progressive disorder. The early diagnosis of degenerative conditions such as Alzheimer's Disease (AD) is particularly important given the continuing development of novel pharmacological agents that show promise in decreasing the rate of progression of memory impairment. Future agents will likely be most effective by limiting the extent of brain impairment when administered early in the development of the disease, making early diagnosis critical.
The purpose of the proposed investigation is to assess the utility, among Hispanic and non-Hispanic elderly who are at risk for cognitive decline, of two newly developed neuropsychological tests: the Semantic Interference Test (SIT) and the Prospective Memory Test (PMT). The SIT assesses proactive and retroactive semantic interference, whereas the PMT assesses event- and time-based prospective memory. Pilot work in our laboratories using English- and Spanish-speaking elderly indicates that vulnerability to semantic interference as measured by the SIT is a more sensitive indicator of cognitive impairment in the early stages of AD than traditional neuropsychological tests that assess delayed memory or rate of forgetting. Our data also indicate that the PMT has good sensitivity and specificity in differentiating mildly impaired AD patients from normal elderly controls.
A unique aspect of this study is that the predictive utility of semantic interference and prospective memory measures will be compared to traditional neuropsychological tests in predicting cognitive decline and progression to dementia among elderly Hispanic and non-Hispanic patients who are normal or who have mild cognitive impairment (MCI). Genetic risk factors such as apolipoprotein E (ApoE) status will also be assessed with regards to its ability to predict, alone and in combination with SIT and PMT measures, which individuals will develop cognitive decline and progression to dementia. The study of increased vulnerability to semantic interference and decline in prospective memory may enhance the detection of MCI and the prediction of progression to dementia in at risk populations, thus having important clinical, heuristic, and treatment implications.
描述(由申请人提供):记忆障碍的患病率随着年龄的增长而增加,这对临床医生提出了挑战,他们必须区分良性病症和严重的进行性障碍。鉴于新型药物制剂的不断发展,这些药物有望降低记忆障碍的进展速度,因此对阿尔茨海默病 (AD) 等退行性疾病的早期诊断尤为重要。未来的药物可能会通过在疾病发展的早期施用来限制大脑损伤的程度来最有效,这使得早期诊断至关重要。
拟议调查的目的是评估两种新开发的神经心理学测试:语义干扰测试(SIT)和前瞻性记忆测试(PMT)在有认知能力下降风险的西班牙裔和非西班牙裔老年人中的效用。 SIT 评估主动和追溯语义干扰,而 PMT 评估基于事件和时间的前瞻性记忆。我们实验室对讲英语和西班牙语的老年人进行的试点工作表明,与评估延迟记忆或遗忘率的传统神经心理学测试相比,SIT 测量的语义干扰脆弱性是 AD 早期认知障碍的更敏感指标。我们的数据还表明,PMT 在区分轻度受损 AD 患者与正常老年对照方面具有良好的敏感性和特异性。
这项研究的一个独特之处在于,将语义干扰和前瞻性记忆测量的预测效用与传统的神经心理学测试进行比较,以预测正常或有轻度认知障碍的老年西班牙裔和非西班牙裔患者的认知能力下降和痴呆进展。 (MCI)。载脂蛋白 E (ApoE) 状态等遗传风险因素也将根据其单独或与 SIT 和 PMT 测量相结合的预测能力进行评估,哪些个体将出现认知能力下降和进展为痴呆症。对语义干扰的脆弱性增加和前瞻性记忆下降的研究可能会增强高危人群中 MCI 的检测和痴呆进展的预测,从而具有重要的临床、启发和治疗意义。
项目成果
期刊论文数量(21)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Severity of medial temporal atrophy and amnestic mild cognitive impairment: selecting type and number of memory tests.
内侧颞萎缩和遗忘性轻度认知障碍的严重程度:选择记忆测试的类型和数量。
- DOI:10.1097/jgp.0b013e3181b7ef42
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:Loewenstein,DavidA;Acevedo,Amarilis;Potter,Elizabeth;Schinka,JohnA;Raj,Ashok;Greig,MariaT;Agron,Joscelyn;Barker,WarrenW;Wu,Yougui;Small,Brent;Schofield,Elizabeth;Duara,Ranjan
- 通讯作者:Duara,Ranjan
The utility of age-specific cut-offs for visual rating of medial temporal atrophy in classifying Alzheimer's disease, MCI and cognitively normal elderly subjects.
- DOI:10.3389/fnagi.2013.00047
- 发表时间:2013
- 期刊:
- 影响因子:4.8
- 作者:Duara R;Loewenstein DA;Shen Q;Barker W;Varon D;Greig MT;Curiel R;Agron J;Santos I;Potter H
- 通讯作者:Potter H
An investigation of PreMCI: subtypes and longitudinal outcomes.
- DOI:10.1016/j.jalz.2011.03.002
- 发表时间:2012-05
- 期刊:
- 影响因子:0
- 作者:Loewenstein DA;Greig MT;Schinka JA;Barker W;Shen Q;Potter E;Raj A;Brooks L;Varon D;Schoenberg M;Banko J;Potter H;Duara R
- 通讯作者:Duara R
The use of amnestic and nonamnestic composite measures at different thresholds in the neuropsychological diagnosis of MCI.
在 MCI 的神经心理学诊断中使用不同阈值的遗忘和非遗忘复合测量。
- DOI:10.1080/13803390600681206
- 发表时间:2007
- 期刊:
- 影响因子:2.2
- 作者:Loewenstein,DavidA;Acevedo,Amarilis;Agron,Joscelyn;Martinez,Glenda;Duara,Ranjan
- 通讯作者:Duara,Ranjan
Evaluating different aspects of prospective memory in amnestic and nonamnestic mild cognitive impairment.
- DOI:10.1155/2014/805929
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:Hernandez Cardenache R;Burguera L;Acevedo A;Curiel R;Loewenstein DA
- 通讯作者:Loewenstein DA
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DAVID LOEWENSTEIN其他文献
DAVID LOEWENSTEIN的其他文献
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{{ truncateString('DAVID LOEWENSTEIN', 18)}}的其他基金
A Novel Computerized Cognitive Stress Test Designed for Clinical Trials in Early Alzheimer's: Relationship with Multimodal Imaging Biomarkers in Diverse Cultural Groups
专为早期阿尔茨海默病临床试验设计的新型计算机认知压力测试:与不同文化群体中多模态成像生物标志物的关系
- 批准号:
10536632 - 财政年份:2019
- 资助金额:
$ 40.52万 - 项目类别:
A Novel Computerized Cognitive Stress Test Designed for Clinical Trials in Early Alzheimer's: Relationship with Multimodal Imaging Biomarkers in Diverse Cultural Groups
专为早期阿尔茨海默病临床试验设计的新型计算机认知压力测试:与不同文化群体中多模态成像生物标志物的关系
- 批准号:
10064122 - 财政年份:2019
- 资助金额:
$ 40.52万 - 项目类别:
A Novel Computerized Cognitive Stress Test Designed for Clinical Trials in Early Alzheimer's: Relationship with Multimodal Imaging Biomarkers in Diverse Cultural Groups
专为早期阿尔茨海默病临床试验设计的新型计算机认知压力测试:与不同文化群体中多模态成像生物标志物的关系
- 批准号:
10322102 - 财政年份:2019
- 资助金额:
$ 40.52万 - 项目类别:
Novel Detection of Early Cognitive and Functional Impairment in the Elderly
老年人早期认知和功能障碍的新检测
- 批准号:
8806184 - 财政年份:2015
- 资助金额:
$ 40.52万 - 项目类别:
Novel Detection of Early Cognitive and Functional Impairment in the Elderly
老年人早期认知和功能障碍的新检测
- 批准号:
9212680 - 财政年份:2015
- 资助金额:
$ 40.52万 - 项目类别:
Exercise Versus Cognitive Interventions for Elders at Risk for Dementia
对于有痴呆症风险的老年人来说,运动与认知干预
- 批准号:
7937900 - 财政年份:2009
- 资助金额:
$ 40.52万 - 项目类别:
Exercise Versus Cognitive Interventions for Elders at Risk for Dementia
对于有痴呆症风险的老年人来说,运动与认知干预
- 批准号:
7833378 - 财政年份:2009
- 资助金额:
$ 40.52万 - 项目类别:
Semantic Intereference and Early Detection of Dementia
语义互指和痴呆症的早期检测
- 批准号:
7056068 - 财政年份:2003
- 资助金额:
$ 40.52万 - 项目类别:
Semantic Interference and Early Detection of Dementia
语义干扰和痴呆症的早期检测
- 批准号:
6578347 - 财政年份:2003
- 资助金额:
$ 40.52万 - 项目类别:
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