MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AW

指导以患者为导向的研究职业发展 AW

• 批准号: 6911761
• 负责人: JAMES H STEIN
• 金额: $ 13.63万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6911761
• 关键词: HIV infections; antiviral agents; atherosclerosis; blood lipoprotein metabolism; carotid artery; cholesterol; chylomicrons; human immunodeficiency virus 1; human subject; human therapy evaluation; hyperlipidemia; low density lipoprotein receptor; medical complication; microorganism disease chemotherapy; patient oriented research; protease inhibitor; triglycerides; ultrasound blood flow measurement; vascular endothelium

PROPOSAL: (Adapted from the applicant's abstract): Dr. Stein will develop a career in patient-oriented research by obtaining advanced training in clinical research design, biostatistics, lipoprotein biochemistry, and advanced ultrasound research techniques. He also will receive training in the ethical conduct of human subjects research. His long-term goal is to become a nationally and internationally recognized clinical investigator who develops therapeutic strategies and tests for the diagnosis and management of patients with or at risk for atherosclerotic vascular disease. As part of his research career development plan, Dr. Stein will complete the UWMS Clinical Investigator Preparatory Pathway (CIPP). As part of this program, he will obtain advanced training in research design, biostatistics, and epidemiology through courses and directed study in the UWMS Biostatistics and Medical Informatics Statistical Data Analysis Center. He will obtain training in lipoprotein biochemistry and lipid laboratory techniques through courses and directed study in the UWMS Hospital Lipid and Lipoprotein Laboratory. He will obtain training in advanced carotid ultrasound research techniques in the Center for Medical Ultrasound at Wake Forest University (WFU). Additional instruction regarding ethics and human subjects research regulations, leadership, teaching, and scientific writing are components of the career development plan. The research plan will determine whether the metabolic changes associated with use of human immunodeficiency virus (HIV) protease inhibitors are atherogenic, as determined by their effects on endothelial function (measured by flow-mediated vasodilation of the brachial artery) and early atherosclerosis (measured by carotid intimal-medial thickening). Abnormalities of these parameters, which are obtained by vascular ultrasound techniques, predict adverse cardiovascular events. Dr. Stein also will assess the effects of HIV protease inhibitors on atherogenic lipoproteins using the advanced lipid laboratory skills he obtains in the career development plan. Finally, Dr. Stein will determine if these medications impair postprandial clearance of triglyceride-containing lipoproteins by assessing lipid and lipoprotein responses to an oral fat load.

提案：（改编自申请人的摘要）：Stein 博士将开发一种 通过获得临床高级培训，从事以患者为导向的研究职业 研究设计、生物统计学、脂蛋白生物化学和高级 超声研究技术。 他还将接受道德培训 进行人类受试者研究。 他的长期目标是成为一名 国内和国际公认的临床研究者，开发 用于患者诊断和管理的治疗策略和测试 患有动脉粥样硬化性血管疾病或有患动脉粥样硬化性血管疾病的风险。 作为他研究的一部分 职业发展计划，Stein 博士将完成 UWMS 临床 研究者预备途径 (CIPP)。 作为该计划的一部分，他将 获得研究设计、生物统计学和流行病学方面的高级培训 通过 UWMS 生物统计和医学课程和定向学习 信息学统计数据分析中心。 他将接受以下方面的培训 通过课程学习脂蛋白生物化学和脂质实验室技术 UWMS 医院脂质和脂蛋白实验室的指导研究。 他会 获得先进颈动脉超声研究技术的培训 维克森林大学 (WFU) 医学超声中心。 额外的 有关伦理和人类受试者研究法规的指示， 领导力、教学和科学写作是职业生涯的组成部分 发展计划。 该研究计划将确定代谢是否 与使用人类免疫缺陷病毒 (HIV) 蛋白酶相关的变化 抑制剂是致动脉粥样硬化的，这取决于它们对内皮细胞的影响 功能（通过肱动脉血流介导的血管舒张来测量）和 早期动脉粥样硬化（通过颈动脉内膜内侧增厚来测量）。 通过血管超声获得的这些参数的异常 技术，预测不良心血管事件。 斯坦博士还将评估 HIV蛋白酶抑制剂对致动脉粥样硬化脂蛋白的影响 他在职业发展计划中获得了先进的脂质实验室技能。 最后，斯坦博士将确定这些药物是否会损害餐后 通过评估脂质和含甘油三酯的脂蛋白的清除率 脂蛋白对口腔脂肪负荷的反应。

项目成果

Does detection of carotid plaque affect physician behavior or motivate patients?

颈动脉斑块的检测是否会影响医生的行为或激励患者？

• 发表时间: 2007-12
• 影响因子: 4.8
• 作者: Wyman, Rachael A;Gimelli, Giorgio;McBride, Patrick E;Korcarz, Claudia E;Stein, James H
• 通讯作者: Stein, James H

Outcomes in 45 patients with statin-associated myopathy.

45 名他汀类药物相关肌病患者的结果。

• 发表时间: 2005-12-12
• 作者: Hansen, Karen E;Hildebrand, Julie P;Ferguson, Edwin E;Stein, James H
• 通讯作者: Stein, James H

Should advanced lipoprotein testing be used in clinical practice?

临床实践中是否应该使用先进的脂蛋白检测？

• 发表时间: 2006-12
• 作者: Stein, James H;McBride, Patrick E
• 通讯作者: McBride, Patrick E

Is the ankle-brachial index a useful screening test for subclinical atherosclerosis in asymptomatic, middle-aged adults?

踝臂指数对于无症状中年人的亚临床动脉粥样硬化筛查有用吗？

• 发表时间: 2006-09
• 作者: Wyman, Rachael A;Keevil, Jon G;Busse, Kjersten L;Aeschlimann, Susan E;Korcarz, Claudia E;Stein, James H
• 通讯作者: Stein, James H

Implications of cardiac risk and low-density lipoprotein cholesterol distributions in the United States for the diagnosis and treatment of dyslipidemia: data from National Health and Nutrition Examination Survey 1999 to 2002.

美国心脏风险和低密度脂蛋白胆固醇分布对血脂异常诊断和治疗的影响：来自 1999 年至 2002 年国家健康和营养检查调查的数据。

• 发表时间: 2007-03-20
• 影响因子: 37.8
• 作者: Keevil, Jon G;Cullen, Michael W;Gangnon, Ronald;McBride, Patrick E;Stein, James H
• 通讯作者: Stein, James H