EVALUATION OF HYPERCAPNIA-INDUCED CHANGES IN CFV BY TTDE IN HEALTHY SUBJECTS

通过 TTDE 评估健康受试者中高碳酸血症引起的 CFV 变化

• 批准号: 7375546
• 负责人: JAMES H STEIN
• 金额: $ 0.71万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375546
• 关键词: EVALUATION; HYPERCAPNIA; INDUCED; CHANGES; CFV

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is completed. Background: The effect of hypercapnia on the coronary arteries in humans is currently unknown. This pilot study assessed the feasibility of using transthoracic Doppler echocardiography (TTDE) in healthy adults to detect changes in coronary artery blood flow velocity (CFV) with varying levels of inspired CO2. Methods: Healthy adults underwent TTDE of the distal left anterior descending coronary artery (LAD) while breathing room air, oxygen supplemented to 40% of inspired air, and CO2 adjusted to +5, +7.5, and +10 mm Hg above their baseline partial end-tidal CO2 (PET CO2) levels on a background of 40% FiO2. CFV and other parameters were measured at each experimental state. Mean peak diastolic CFV values were compared at each state using one-way analysis of variance of repeated measures. Results: Among twenty adults (mean [standard deviation] age 33 [6] years, 52% female, 90% white), TTDE images could be acquired at all experimental conditions in 17 subjects. In order of room-air, 40%FiO2, and +5, +7.5, and +10 mm Hg PETCO2 conditions, mean peak (SD) CFV values were 23.1 (9.1) cm/s, 23.0 (9.0) cm/s, 25.5 (9.3) cm/s, 27.9 (11.5) cm/s, and 31.5 (13.0) cm/s. Between-treatment differences were significantly different (p0.001), with p0.05 between progressive levels of hypercapnia, adjusted for multiple comparisons. No significant CFV differences were seen between baseline conditions or between respective baseline and +5 mm Hg PETCO2 states. Conclusions: With progressive levels of hypercapnia, CFV of the LAD in healthy subjects was observed to increase, and these changes could be detected by TTDE.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。本研究已完成。 背景：高碳酸血症对人类冠状动脉的影响目前尚不清楚。这项初步研究评估了在健康成人中使用经胸多普勒超声心动图 (TTDE) 检测冠状动脉血流速度 (CFV) 随不同吸入 CO2 水平变化的可行性。 方法：健康成年人接受远端左冠状动脉前降支 (LAD) 的 TTDE，同时呼吸室内空气，补充氧气至吸入空气的 40%，并将 CO2 调整至比基线部分高 +5、+7.5 和 +10 mm Hg。 40% FiO2 背景下的潮气末 CO2 (PET CO2) 水平。在每个实验状态下测量 CFV 和其他参数。使用重复测量的单向方差分析来比较每个状态下的平均峰值舒张压 CFV 值。 结果：在 20 名成年人（平均 [标准差] 年龄 33 [6] 岁，52% 女性，90% 白人）中，17 名受试者在所有实验条件下都可以获得 TTDE 图像。按照室内空气、40%FiO2、+5、+7.5 和 +10 mm Hg PETCO2 条件的顺序，平均峰值 (SD) CFV 值为 23.1 (9.1) cm/s、23.0 (9.0) cm/s、 9.3 (25.5) 厘米/秒、11.5 (27.9) 厘米/秒和 13.0 (31.5)厘米/秒。治疗间差异显着不同 (p0.001)，高碳酸血症进展水平之间的差异为 p0.05，并根据多重比较进行调整。基线条件之间或相应基线和+5 mm Hg PETCO2 状态之间没有观察到显着的 CFV 差异。 结论：随着高碳酸血症水平的进展，观察到健康受试者 LAD 的 CFV 增加，并且这些变化可以通过 TTDE 检测到。