Osteoarthritis: prevention and treatment

骨关节炎：预防和治疗

• 批准号: 6847763
• 负责人: Thomas S Buchanan
• 金额: $ 121.07万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-23 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6847763
• 关键词: arthritis therapy; clinical research; disease /disorder prevention /control; knee; osteoarthritis

We propose to establish a center of biomedical research excellence at the University of Delaware that will focus on the prevention and treatment of osteoarthritis. This proposal involves three research projects, each lead by a junior faculty member who will be mentored by senior faculty. In Project 1, Dr. Manal proposes to use a biomedical model based on MRI and electromyographic data to examine knee kinematics and kinetics while performing activities of daily living. Project 2: In-shoe wedges have been shown to be an effective conservative approach in reducing pain in patients with osteoarthritis. The mechanism responsible for this pain reduction is not well understood. In our third project, Dr. Royer proposes to examine the examine the effects of in-shoe wedges in patients with knee OA on static alignment measures. In addition, the long-term effect of this treatment will also be examined. In Project 3, Dr. Rudolph proposes to study genu varum ("bowleggedness"), which often leads to arthritis on the medial compartment of the knee. Surgery is often performed to correct the alignment of the knee in people with genu varum by removing a wedge of bone on the lateral side of the tibia just below the knee joint to align the joint surfaces more normally (closing wedge osteotomy). Removing bone can increase the laxity of the joint capsule, muscles, and ligaments around the knee and may lead to increased problems with biomechanics and muscular responses. An alternative surgery, the opening wedge osteotomy involves the creation of an opening on the medial side of the tibia which can be distracted slowly over time. The purpose of this study is to characterize the differences in movement and muscle activity before and after an opening wedge osteotomy with callus distraction to correct genu varum.

我们建议在特拉华大学建立卓越生物医学研究中心，该中心将重点介绍预防和治疗骨关节炎。该建议涉及三个研究项目，每个研究项目由一名初级教师领导，他们将由高级教师指导。在项目1中，Manal博士建议使用基于MRI和肌电图数据的生物医学模型在进行日常生活活动时检查膝盖运动学和动力学。项目2：在造成的楔形物已被证明是减轻骨关节炎患者疼痛的有效保守方法。导致这种减轻疼痛的机制尚不清楚。在我们的第三个项目中，Royer博士建议检查检查鞋管楔在膝盖OA患者对静态比对措施的影响。此外，还将检查这种治疗方法的长期效果。在项目3中，鲁道夫博士建议研究真正的杂色（“ Bowleggedness”），这通常会导致膝盖内侧腔室的关节炎。通常，通过在膝盖关节下方的胫骨的侧面去除一块骨头，以更正常（闭合的楔形骨切开术）来对齐，通常进行手术以纠正膝盖的对齐。去除骨骼会增加膝盖周围关节囊，肌肉和韧带的松弛度，并可能导致生物力学和肌肉反应的问题增加。开口楔截骨术是另一种手术，涉及在胫骨内侧的开口创建，随着时间的流逝，可以缓慢分散注意力。这项研究的目的是表征开放楔形截骨术之前和之后的运动和肌肉活动的差异，并分散了愈伤组织，以纠正真正的杂色。