Osteoarthritis: Prevention and Treatment

骨关节炎：预防和治疗

基本信息

批准号：
9330254
负责人：
Thomas S Buchanan
金额：
$ 27.36万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-01 至 2018-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9330254
关键词：
Address Advisory Committees Affect American Arthritis Award Biomechanics Biometry Cartilage Centers of Research Excellence Clinical Clinical Research Clinical Trials Collection Coupled Databases Degenerative polyarthritis Delaware Development Disease Engineering Extracellular Matrix Proteins Faculty Feedback Foundations Funding Future Goals Grant Health Human Joints Life Ligaments Mechanics Medicine Mentors Modeling Modification Motion Muscle Orthopedics Outcome Study Pathology Patient-Focused Outcomes Patients Phase Pilot Projects Prevention Rehabilitation therapy Research Research Infrastructure Research Personnel Resources Running Science Stress Teacher Professional Development Testing Time Tissues United States National Institutes of Health Universities Woman Work base bioimaging biomechanical model bone improved member multidisciplinary personalized medicine success tool translational approach trend women faculty

项目摘要

DESCRIPTION (provided by applicant): We propose to build on the successes of our of past COBRE phase I and II grants to create a collection of three research cores that, coupled with a pilot project mechanism, will provide us with the resources to develop a strong team of investigators to study the prevention and treatment of osteoarthritis. Ours is a multidisciplinary, multi-scale approach to the study of osteoarthritis (OA), involving faculty doing work in extracellular matrix proteins, biomechanical modeling of joint forces, and clinical studies. The uniqueness of our approach will be the examination of OA from the integrated perspectives of tissue mechanics, biomechanics, and rehabilitation. We will build on the distinctive organization of the center established with the COBRE award and the collaborative projects described in this application. Three core resources will be run through this award: (1) A cytomechanics core, first established in our phase II grant, will be strengthened to provide tools for orthopaedic researchers to study how bone, cartilage and ligament respond to stress and strain. This involves tools for bioimaging and micromechanical testing. (2) A patient specific modeling (PSM) core will be established. This is a modification and expansion of the motion analysis core established in our COBRE I award. It will provide a means to determine differences in tissue forces associated with pathologies and will also be used to determine biomechanical differences associated with various treatment paths, which may impact the development of osteoarthritis. (3) A clinical research core (the ResCore) will be established for the first time to aid us as we expand our clinical trials. It will provide patient database access and biostatistics support for al projects. In addition, we will continue to maintain our mentoring mechanism. Faculty development is key to our success and we will continue to mentor our faculty and work with our External Advisory Committee to provide very regular feedback to COBRE investigators about their research. Our goal is to use these resources to establish a large base of NIH R01 funded investigators studying osteoarthritis and, by those R01 grants, be able to support our cores in the future and greatly expand our efforts to make strong progress in understanding the prevention and treatment of OA.

描述（由申请人提供）：我们建议以过去的第一阶段和第二阶段的赠款的成功为基础，以创建三个研究核心的集合，再加上试验项目机制，将为我们提供资源，以开发强大的研究人员，以研究预防和治疗骨关节炎。我们的是一个多学科，多尺度研究骨关节炎（OA）的多尺度方法，涉及从事细胞外基质蛋白的工作，关节力的生物力学建模和临床研究。我们方法的独特性将是从组织力学，生物力学和康复的综合角度检查OA。我们将建立在该中心建立的中心的独特组织和本申请中描述的协作项目的基础上。该奖项将通过三个核心资源进行：（1）首先在我们的II期赠款中建立的细胞力学核心将得到加强，为骨科研究人员提供工具，以研究骨骼，软骨和韧带如何应对压力和压力。这涉及生物成像和微力测试的工具。（2）将建立特定于患者的建模（PSM）核心。这是在我们授予的山毛上建立的运动分析核心的修改和扩展。它将提供一种确定与病理相关的组织力差异的方法，还将用于确定与各种治疗路径相关的生物力学差异，这可能会影响骨关节炎的发展。（3）将首次建立临床研究核心（撤退），以帮助我们扩大临床试验。它将为AL项目提供患者数据库访问和生物统计学支持。此外，我们将继续保持我们的指导机制。教师发展是我们成功的关键，我们将继续指导我们的教职员工，并与我们的外部咨询委员会合作，向Cobre调查人员提供有关其研究的非常定期的反馈。我们的目标是利用这些资源来建立研究骨关节炎的NIH R01资助的研究人员，并通过R01赠款，能够在将来支持我们的核心，并大大扩展我们在理解预防和治疗OA方面取得强大进展的努力。