Osteoarthritis: Prevention and Treatment

骨关节炎：预防和治疗

• 批准号: 8518409
• 负责人: Thomas S Buchanan
• 金额: $ 107.19万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8518409
• 关键词: Address; Advisory Committees; Affect; American; Arthritis; Award; Biomechanics; Biometry; Cartilage; Centers of Research Excellence; Clinical; Clinical Research; Clinical Trials; Collection; Coupled; Databases; Degenerative polyarthritis; Delaware; Development; Disease; Engineering; Extracellular Matrix Proteins; Faculty; Feedback; Foundations; Funding; Future; Goals; Grant; Human; Joints; Life; Ligaments; Mechanics; Medicine; Mentors; Modeling; Modification; Motion; Muscle; Orthopedics; Outcome; Outcome Study; Pathology; Patients; Phase; Pilot Projects; Prevention; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Resources; Running; Science; Stress; Testing; Time; Tissues; United States National Institutes of Health; Universities; Woman; Work; base; bioimaging; bone; improved; member; multidisciplinary; public health relevance; success; tool; translational approach; trend

DESCRIPTION (provided by applicant): We propose to build on the successes of our of past COBRE phase I and II grants to create a collection of three research cores that, coupled with a pilot project mechanism, will provide us with the resources to develop a strong team of investigators to study the prevention and treatment of osteoarthritis. Ours is a multidisciplinary, multi-scale approach to the study of osteoarthritis (OA), involving faculty doing work in extracellular matrix proteins, biomechanical modeling of joint forces, and clinical studies. The uniqueness of our approach will be the examination of OA from the integrated perspectives of tissue mechanics, biomechanics, and rehabilitation. We will build on the distinctive organization of the center established with the COBRE award and the collaborative projects described in this application. Three core resources will be run through this award: (1) A cytomechanics core, first established in our phase II grant, will be strengthened to provide tools for orthopaedic researchers to study how bone, cartilage and ligament respond to stress and strain. This involves tools for bioimaging and micromechanical testing. (2) A patient specific modeling (PSM) core will be established. This is a modification and expansion of the motion analysis core established in our COBRE I award. It will provide a means to determine differences in tissue forces associated with pathologies and will also be used to determine biomechanical differences associated with various treatment paths, which may impact the development of osteoarthritis. (3) A clinical research core (the ResCore) will be established for the first time to aid us as we expand our clinical trials. It will provide patient database access and biostatistics support for al projects. In addition, we will continue to maintain our mentoring mechanism. Faculty development is key to our success and we will continue to mentor our faculty and work with our External Advisory Committee to provide very regular feedback to COBRE investigators about their research. Our goal is to use these resources to establish a large base of NIH R01 funded investigators studying osteoarthritis and, by those R01 grants, be able to support our cores in the future and greatly expand our efforts to make strong progress in understanding the prevention and treatment of OA.

描述（由申请人提供）：我们建议在过去 COBRE 第一阶段和第二阶段拨款的成功基础上创建三个研究核心的集合，再加上试点项目机制，将为我们提供资源来开发强大的研究团队致力于研究骨关节炎的预防和治疗。我们是一个多学科、 骨关节炎（OA）研究的多尺度方法，涉及从事细胞外基质蛋白、关节力生物力学建模和临床研究工作的教师。我们方法的独特之处在于从组织力学、生物力学和康复的综合角度来检查骨关节炎。我们将以 COBRE 奖建立的中心的独特组织和本申请中描述的合作项目为基础。该奖项将运行三个核心资源：（1）我们的第二阶段拨款中首次建立的细胞力学核心将得到加强，为骨科研究人员提供研究骨骼、软骨和韧带如何响应压力和应变的工具。这涉及生物成像和微机械测试工具。 (2)建立患者特异性模型(PSM)核心。这是对我们 COBRE I 奖项中建立的运动分析核心的修改和扩展。它将提供一种方法来确定与病理相关的组织力的差异，还将用于确定与各种治疗路径相关的生物力学差异，这可能会影响骨关节炎的发展。 （3）将首次建立临床研究核心（ResCore），以帮助我们扩大临床试验。它将为所有项目提供患者数据库访问和生物统计支持。此外，我们将继续维持我们的指导机制。教师发展是我们成功的关键，我们将继续指导我们的教师并与外部咨询委员会合作，定期向 COBRE 研究人员提供有关其研究的反馈。我们的目标是利用这些资源建立一个由 NIH R01 资助的研究骨关节炎研究人员的大型基地，并通过这些 R01 资助，能够支持我们未来的核心工作，并大大扩展我们的努力，在了解预防和治疗方面取得重大进展OA。